TPDB

3D PDB MODEL

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TPDB ID TPDB04391

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

FLTGVLKLASKIPSVLCAVLKTC

FASTA

>TPDB04391|Antibacterial;Antifungal|length=23
FLTGVLKLASKIPSVLCAVLKTC

Formula C111H194N26O28S2

Absent Amino Acids RNDEQHMWY

Common Amino Acids L

Mass 2405.04

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +3

Boman Index -0.88

Hydrophobicity 1.339

Aliphatic Index 148.26

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.20

Polar Residues 6

number

2

A

0

R

0

N

0

D

2

C

0

E

0

Q

1

G

0

H

1

I

5

L

3

K

0

M

1

F

1

P

2

S

2

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 5 K: 3 M: 0 F: 1 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 3

Length

23

Formula

C111H194N26O28S2

Mass

2405.04

PI

9.80

Net Charge

+3

Boman Index

-0.88

Hydrophobicity

1.339

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source NA

Other

Evidence Text

inst Gram+ bacteria E.faecium 091299 (IS) (MIC 150 uM), E. faecalis 981 (IS) (MIC 19 uM), S. aureus ATCC25923 (MIC 19 uM), S. carnosus KHS (IS) (MIC 37.5 uM), B. licheniformis X39 (IS) (MIC 37.5 uM), R. rhodochr

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism E.coli ATCC25922

Source & Reference

Database Source NA

Other

Evidence Text

uM), B. licheniformis X39 (IS) (MIC 37.5 uM), R. rhodochrous X15 (IS)(MIC 4.8 uM), Gram- E.coli ATCC25922 (MIC >150 uM), S.typhi 091408 (IS)(MIC >150 uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P.aeruginosa (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC10231

Source & Reference

Database Source NA

Other

Evidence Text

M), P.aeruginosa (ATCC27853) (MIC >150 uM), P. faecalis X29 (IS) (MIC 37.5 uM), and fungi C.albicans ATCC10231 (MIC>150 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source Antifungipept

Other

Evidence Text

inst Gram+ bacteria E.faecium 091299 (IS) (MIC 150 uM), E. faecalis 981 (IS) (MIC 19 uM), S. aureus ATCC25923 (MIC 19 uM), S. carnosus KHS (IS) (MIC 37.5 uM), B. licheniformis X39 (IS) (MIC 37.5 uM), R. rhodochr

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism E.coli ATCC25922

Source & Reference

Database Source Antifungipept

Other

Evidence Text

uM), B. licheniformis X39 (IS) (MIC 37.5 uM), R. rhodochrous X15 (IS)(MIC 4.8 uM), Gram- E.coli ATCC25922 (MIC >150 uM), S.typhi 091408 (IS)(MIC >150 uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P.aeruginosa (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC10231

Source & Reference

Database Source Antifungipept

Other

Evidence Text

M), P.aeruginosa (ATCC27853) (MIC >150 uM), P. faecalis X29 (IS) (MIC 37.5 uM), and fungi C.albicans ATCC10231 (MIC>150 uM).