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Peptide record

TPDB04385

Antibacterial Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB04385
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
YSLQMGATAIKQVKKLFKKKGG
Physicochemical Analysis
C111H190N30O28S1
RNDCEHPW
K
2424.97
10.87
6
0
9
+6
3.40
-0.445
75.45
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
61.44
5
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
1
I
2
L
6
K
1
M
1
F
0
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 1 L: 2 K: 6 M: 1 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
22
C111H190N30O28S1
2424.97
10.87
+6
3.40
-0.445
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Pln149a was active against one strain of S. aureus and four strains of Listeria genus at pH 5.5 and 7.4 and, like its natural form, inhibited L. plantarum ATCC 8014.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Pln149a was active against one strain of S. aureus and four strains of Listeria genus at pH 5.5 and 7.4 and, like its natural form, inhibited L. plantarum ATCC 8014.
Evidence 3 Activity

Activity

7% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
7% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Interaction of acylated and substituted antimicrobial peptide analogs with phospholipid-polydiacetylene vesicles. Correlation with their biological properties. | Chem Biol Drug Des | 2011
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
400 µM
Hemolytic Cytotoxic
10% Hemolysis | 400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Interaction of acylated and substituted antimicrobial peptide analogs with phospholipid-polydiacetylene vesicles. Correlation with their biological properties. | Chem Biol Drug Des | 2011