TPDB

3D PDB MODEL

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TPDB ID TPDB04334

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RWSVYAYVRVRGVLVRYRRSW

FASTA

>TPDB04334|Antibacterial;Toxicity|length=21
RWSVYAYVRVRGVLVRYRRSW

Formula C127H195N41O27

Absent Amino Acids NDCEQHIKMFPT

Common Amino Acids R

Mass 2728.20

PI 12.11

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +6

Boman Index -1.77

Hydrophobicity -0.386

Aliphatic Index 92.38

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 15470

Absorbance 280nm 567.04

Polar Residues 5

number

1

A

6

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

2

S

0

T

2

W

3

Y

5

V

Amino Acid Distribution

A: 1 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 2 T: 0 W: 2 Y: 3 V: 5

Length

21

Formula

C127H195N41O27

Mass

2728.20

PI

12.11

Net Charge

+6

Boman Index

-1.77

Hydrophobicity

-0.386

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Escherichia coli KCTC 1682

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli KCTC 1682 (MIC 16 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S.aureus KCTC 1621 (MIC 4 uM), and S. epidermidis KC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa KCTC 1637

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli KCTC 1682 (MIC 16 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S.aureus KCTC 1621 (MIC 4 uM), and S. epidermidis KCTC 1917 (MIC 8 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S.aureus KCTC 1621

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli KCTC 1682 (MIC 16 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S.aureus KCTC 1621 (MIC 4 uM), and S. epidermidis KCTC 1917 (MIC 8 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis KCTC 1917

Source & Reference

Database Source NA

Other

Evidence Text

1682 (MIC 16 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S.aureus KCTC 1621 (MIC 4 uM), and S. epidermidis KCTC 1917 (MIC 8 uM).