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Peptide record

TPDB04330

Antibacterial Antifungal standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04330
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ASSGWVCTLTIECGTVICACR
Physicochemical Analysis
C90H149N25O29S4
NDQHKMFPY
C
2173.56
5.99
1
1
8
-0
-0.66
1.019
92.86
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5750
264.54
9
Residue Composition
number
2
A
1
R
0
N
0
D
4
C
1
E
0
Q
2
G
0
H
2
I
1
L
0
K
0
M
0
F
0
P
2
S
3
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 4 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 2 T: 3 W: 1 Y: 0 V: 2
Chemical Descriptors
21
C90H149N25O29S4
2173.56
5.99
-0
-0.66
1.019
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus MetS ATCC 6538P

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against S. aureus MetS ATCC 6538P (MIC 8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogen
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus MetS ATCC 19636

Source & Reference

dbAMP DRAMP

Other

active against S. aureus MetS ATCC 6538P (MIC 8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Staphylococcus aureus MetR L1400

Source & Reference

dbAMP DRAMP

Other

gainst S. aureus MetS ATCC 6538P (MIC 8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L5
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

Streptococcus pyogenes SKF13400

Source & Reference

dbAMP DRAMP

Other

8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L5
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

S. pneumoniae L44

Source & Reference

dbAMP DRAMP

Other

MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

E.faecium VanS L568

Source & Reference

dbAMP DRAMP

Other

00 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), a
Evidence 7 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

Enterococcus faecalis VanS L559 or VanA L560

Source & Reference

dbAMP DRAMP

Other

00 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), and C.albicans ATCC 90028 (MIC >128 ug/ml). Very act
Evidence 8 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

E.coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

, E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), and C.albicans ATCC 90028 (MIC >128 ug/ml). Very active against anaerobic bacteria C. di
Evidence 9 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

C.albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), and C.albicans ATCC 90028 (MIC >128 ug/ml). Very active against anaerobic bacteria C. difficile L4013, L1365, or L4015 (MIC 0.25-2 u
Evidence 10 Activity

Activity

MIC
Antibacterial
0.25 µg/mL

Target

C. butyricum L4008

Source & Reference

dbAMP DRAMP

Other

active against anaerobic bacteria C. difficile L4013, L1365, or L4015 (MIC 0.25-2 ug/ml), C. butyricum L4008 (MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyti
Evidence 11 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Clostridium perfringens L4053

Source & Reference

dbAMP DRAMP

Other

difficile L4013, L1365, or L4015 (MIC 0.25-2 ug/ml), C. butyricum L4008 (MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fr
Evidence 12 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Clostridium perfringens L3607

Source & Reference

dbAMP DRAMP

Other

C 0.25-2 ug/ml), C. butyricum L4008 (MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fragilis ATCC 25285 (MIC >128 ug/ml).
Evidence 13 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

Peptostreptococcus asaccharolyticus L521

Source & Reference

dbAMP DRAMP

Other

(MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fragilis ATCC 25285 (MIC >128 ug/ml).
Evidence 14 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

B.fragilis ATCC 25285

Source & Reference

dbAMP DRAMP

Other

/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fragilis ATCC 25285 (MIC >128 ug/ml).
Evidence 15 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus MetS ATCC 6538P

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against S. aureus MetS ATCC 6538P (MIC 8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogen
Evidence 16 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus MetS ATCC 19636

Source & Reference

dbAMP DRAMP Antifungipept

Other

active against S. aureus MetS ATCC 6538P (MIC 8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae
Evidence 17 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Staphylococcus aureus MetR L1400

Source & Reference

dbAMP DRAMP Antifungipept

Other

gainst S. aureus MetS ATCC 6538P (MIC 8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L5
Evidence 18 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

Streptococcus pyogenes SKF13400

Source & Reference

dbAMP DRAMP Antifungipept

Other

8 ug/ml), S. aureus MetS ATCC 19636 (MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L5
Evidence 19 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

S. pneumoniae L44

Source & Reference

dbAMP DRAMP Antifungipept

Other

MIC 16 ug/ml), S. aureus MetR L1400 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml),
Evidence 20 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

E.faecium VanS L568

Source & Reference

dbAMP DRAMP Antifungipept

Other

00 (MIC 32 ug/ml), S. pyogenes SKF13400 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), a
Evidence 21 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

Enterococcus faecalis VanS L559 or VanA L560

Source & Reference

dbAMP DRAMP Antifungipept

Other

00 (MIC 0.5 ug/ml), S. pneumoniae L44 (MIC 8 ug/ml), E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), and C.albicans ATCC 90028 (MIC >128 ug/ml). Very act
Evidence 22 Activity

Activity

MIC
Antifungal
>128 µg/mL

Target

E.coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

, E.faecium VanS L568 (MIC 128 ug/ml), E.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), and C.albicans ATCC 90028 (MIC >128 ug/ml). Very active against anaerobic bacteria C. di
Evidence 23 Activity

Activity

MIC
Antifungal
>128 µg/mL

Target

C.albicans ATCC 90028

Source & Reference

dbAMP DRAMP Antifungipept

Other

.faecalis VanS L559 or VanA L560 (MIC 128 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), and C.albicans ATCC 90028 (MIC >128 ug/ml). Very active against anaerobic bacteria C. difficile L4013, L1365, or L4015 (MIC 0.25-2 u
Evidence 24 Activity

Activity

MIC
Antifungal
0.25 µg/mL

Target

C. butyricum L4008

Source & Reference

dbAMP DRAMP Antifungipept

Other

active against anaerobic bacteria C. difficile L4013, L1365, or L4015 (MIC 0.25-2 ug/ml), C. butyricum L4008 (MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyti
Evidence 25 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Clostridium perfringens L4053

Source & Reference

dbAMP DRAMP Antifungipept

Other

difficile L4013, L1365, or L4015 (MIC 0.25-2 ug/ml), C. butyricum L4008 (MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fr
Evidence 26 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Clostridium perfringens L3607

Source & Reference

dbAMP DRAMP Antifungipept

Other

C 0.25-2 ug/ml), C. butyricum L4008 (MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fragilis ATCC 25285 (MIC >128 ug/ml).
Evidence 27 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

Peptostreptococcus asaccharolyticus L521

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 0.25 ug/ml), C. perfringens L4053 (MIC 2 ug/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fragilis ATCC 25285 (MIC >128 ug/ml).
Evidence 28 Activity

Activity

MIC
Antifungal
>128 µg/mL

Target

B.fragilis ATCC 25285

Source & Reference

dbAMP DRAMP Antifungipept

Other

/ml), C. perfringens L3607 (MIC 2 ug/ml), P. asaccharolyticus L521 (MIC 1 ug/ml), but not B.fragilis ATCC 25285 (MIC >128 ug/ml).