TPDB

3D PDB MODEL

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TPDB ID TPDB04321

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

FIVPSIFLLKKAFCIALKKNC

FASTA

>TPDB04321|Antibacterial;Antifungal|length=21
FIVPSIFLLKKAFCIALKKNC

Formula C116H190N26O24S2

Absent Amino Acids RDEQGHMTWY

Common Amino Acids K

Mass 2397.06

PI 10.17

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +4

Boman Index -1.79

Hydrophobicity 1.171

Aliphatic Index 134.76

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.21

Polar Residues 4

number

2

A

0

R

1

N

0

D

2

C

0

E

0

Q

0

G

0

H

3

I

3

L

4

K

0

M

3

F

1

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 3 K: 4 M: 0 F: 3 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

21

Formula

C116H190N26O24S2

Mass

2397.06

PI

10.17

Net Charge

+4

Boman Index

-1.79

Hydrophobicity

1.171

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source NA

Other

Evidence Text

inst Gram+ bacteria E. faecium 091299 (IS) (MIC 75 uM), E. faecalis 981 (IS) (MIC 75 uM), S. aureus ATCC25923 (MIC 19 uM), S. carnosus KHS (IS) (MIC 75 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrous

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism E.coli ATCC25922

Source & Reference

Database Source NA

Other

Evidence Text

75 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrous X15 (IS)(MIC 19 uM), Gram- E.coli ATCC25922 (MIC >150 uM), S.typhi 091408 (IS)(MIC >150 uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P.aeruginosa (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC10231

Source & Reference

Database Source NA

Other

Evidence Text

uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P. faecalis X29 (IS) (MIC 75 uM), and fungi C.albicans ATCC10231 (MIC>150 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source Antifungipept

Other

Evidence Text

inst Gram+ bacteria E. faecium 091299 (IS) (MIC 75 uM), E. faecalis 981 (IS) (MIC 75 uM), S. aureus ATCC25923 (MIC 19 uM), S. carnosus KHS (IS) (MIC 75 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrous

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism E.coli ATCC25922

Source & Reference

Database Source Antifungipept

Other

Evidence Text

75 uM), B. licheniformis X39 (IS) (MIC 19 uM), R. rhodochrous X15 (IS)(MIC 19 uM), Gram- E.coli ATCC25922 (MIC >150 uM), S.typhi 091408 (IS)(MIC >150 uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P.aeruginosa (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC10231

Source & Reference

Database Source Antifungipept

Other

Evidence Text

uM), P.aeruginosa (ATCC27853) (MIC >150 uM), P. faecalis X29 (IS) (MIC 75 uM), and fungi C.albicans ATCC10231 (MIC>150 uM).