TPDB

3D PDB MODEL

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TPDB ID TPDB04287

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

CKQSCSFGPFTFVCDGNTK

FASTA

>TPDB04287|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=19
CKQSCSFGPFTFVCDGNTK

Formula C89H133N23O28S3

Absent Amino Acids AREHILMWY

Common Amino Acids CF

Mass 2069.35

PI 8.01

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 4

Net Charge +1

Boman Index 1.18

Hydrophobicity -0.189

Aliphatic Index 15.26

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.04

Polar Residues 9

number

0

A

0

R

1

N

1

D

3

C

0

E

1

Q

2

G

0

H

0

I

0

L

2

K

0

M

3

F

1

P

2

S

2

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 3 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 3 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 1

Length

19

Formula

C89H133N23O28S3

Mass

2069.35

PI

8.01

Net Charge

+1

Boman Index

1.18

Hydrophobicity

-0.189

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism B. subtilis 168

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against Gram+ B. subtilis 168 (MIC 2 uM), Bacillus BC15 (MIC 3.75 uM), Paenibacillus BC26 (MIC 17.5 uM), Arthrobacter CF158 (MIC 2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism B. subtilis 168

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against Gram+ B. subtilis 168 (MIC 2 uM), Bacillus BC15 (MIC 3.75 uM), Paenibacillus BC26 (MIC 17.5 uM), Arthrobacter CF158 (MIC 2

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism B. subtilis 168

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against Gram+ B. subtilis 168 (MIC 2 uM), Bacillus BC15 (MIC 3.75 uM), Paenibacillus BC26 (MIC 17.5 uM), Arthrobacter CF158 (MIC 2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µM

Target

Target Organism B. subtilis 168

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

active against Gram+ B. subtilis 168 (MIC 2 uM), Bacillus BC15 (MIC 3.75 uM), Paenibacillus BC26 (MIC 17.5 uM), Arthrobacter CF158 (MIC 2