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Peptide record

TPDB04268

RC101 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB04268
RC101
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AI4AVP DRAVP 2.0 CPPsite3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
Sequence
GICRCICGKGICRCICGR
Physicochemical Analysis
C74H136N28O19S6
ANDEQHLMFPSTWYV
C
1914.43
8.60
4
0
4
+4
0.78
0.778
86.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
19.59
6
Residue Composition
number
0
A
3
R
0
N
0
D
6
C
0
E
0
Q
4
G
0
H
4
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 4 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C74H136N28O19S6
1914.43
8.60
+4
0.78
0.778
Free
L
Cyclic
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

inhibit S. aureus USA300 ( Lamers et al., 2011 ), viruses HIV-1, SARS-Cov-2, influenza.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

NA

Other

inhibit S. aureus USA300 ( Lamers et al., 2011 ), viruses HIV-1, SARS-Cov-2, influenza.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

NA

Other

inhibit S. aureus USA300 ( Lamers et al., 2011 ), viruses HIV-1, SARS-Cov-2, influenza.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAVP 2.0

Other

inhibit S. aureus USA300 ( Lamers et al., 2011 ), viruses HIV-1, SARS-Cov-2, influenza.
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Hpdls, Mms, Scc-1, Gmsc, Agk And Obc Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
GFP protein
Periphery And Cytosol
GFP-RC101 entered SCC-1, GMSC, AGK and OBC, but its localization in HPDLSC was negligible and was undetectable in MMSC cells.
In vitro
CCCCHHHHHHHTTC
Additional Detail Fields 1 fields
CCCCHHHHHHHTTC