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Peptide record

TPDB04242

Antibacterial Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB04242
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VGTIIKIIKAIIDIFAK
Physicochemical Analysis
C90H158N20O21
RNCEQHLMPSWY
I
1856.37
10.32
3
1
11
+2
0.78
1.518
189.41
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
7
I
0
L
3
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 7 L: 0 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C90H158N20O21
1856.37
10.32
+2
0.78
1.518
Evidence Records 4 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
52 %
[Ref.22371493]52% hemolysis at 10µg/mL against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Biol Chem. 2012 Apr 20 287(17):13889-98.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

52% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
52% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. | J Biol Chem | 2012
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
52 %
Hemolytic
Hemolytic_activity: [Ref.22371493]52% hemolysis at 10µg/mL against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2012 Apr 20 287(17):13889-98.
Evidence 4 Hemolysis

Activity

52 %
% Hemolysis
[Ref.22371493]52% hemolysis at 10µg/mL against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
J Biol Chem. 2012 Apr 20 287(17):13889-98.
DRAMP4
PD_Hemolysis