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Peptide record

TPDB04217

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB04217
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifp Antifungipept CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RLARIVVIRVAR
Physicochemical Analysis
C63H120N24O13
NDCEQGHKMFPSTWY
R
1421.80
12.88
4
0
8
+4
1.93
0.917
186.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
12
C63H120N24O13
1421.80
12.88
+4
1.93
0.917
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Pseudomonas aeruginosa H103

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aure
Evidence 2 Activity

Activity

MIC
Antibacterial
17 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

active against P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17
Evidence 3 Activity

Activity

MIC
Antibacterial
34 µM

Target

S. Typhimurium

Source & Reference

dbAMP DRAMP

Other

inst P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis
Evidence 4 Activity

Activity

MIC
Antibacterial
17 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. alb
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis clinical strain

Source & Reference

dbAMP DRAMP

Other

enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
17 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP

Other

(MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
9 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
50 µM

Target

Pseudomonas aeruginosa H103

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aure
Evidence 9 Activity

Activity

MIC
Antifungal
17 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17
Evidence 10 Activity

Activity

MIC
Antifungal
34 µM

Target

S. Typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis
Evidence 11 Activity

Activity

MIC
Antifungal
17 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. alb
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus epidermidis clinical strain

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
17 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
9 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Pseudomonas aeruginosa H103

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aure
Evidence 16 Activity

Activity

MIC
Antiparasitic
17 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

active against P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17
Evidence 17 Activity

Activity

MIC
Antiparasitic
34 µM

Target

S. Typhimurium

Source & Reference

DRAMP

Other

inst P. aeruginosa H103 (MIC 50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis
Evidence 18 Activity

Activity

MIC
Antiparasitic
17 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

50 uM), E. coli (MIC 17 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. alb
Evidence 19 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Staphylococcus epidermidis clinical strain

Source & Reference

DRAMP

Other

enterica ssp. Typhimurium or S. Typhimurium (MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 20 Activity

Activity

MIC
Antiparasitic
17 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

DRAMP

Other

(MIC 34 uM). S. aureus ATCC25923 (MIC 17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 21 Activity

Activity

MIC
Antiparasitic
9 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

17 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 17 uM), and C. albicans (MIC 9 uM).
Evidence 22 Activity

Activity

0% Hemolysis
Toxicity
188 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 188 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. | ACS Chem Biol | 2009