TPDB

3D PDB MODEL

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TPDB ID TPDB04190

Peptide_Name

Temporin-1CEb

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ILPILSLIGGLLGK

FASTA

>TPDB04190|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=14
ILPILSLIGGLLGK

Formula C68H123N15O16

Absent Amino Acids ARNDCEQHMFTWYV

Common Amino Acids L

Mass 1406.82

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +1

Boman Index -2.13

Hydrophobicity 1.786

Aliphatic Index 222.86

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

3

G

0

H

3

I

5

L

1

K

0

M

0

F

1

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 3 L: 5 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

14

Formula

C68H123N15O16

Mass

1406.82

PI

10.10

Net Charge

+1

Boman Index

-2.13

Hydrophobicity

1.786

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Rana chensinensis, China, Asia

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 41 µM

Target

Target Organism S. lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aureus, B. cereus, S. lactis (MIC 41 uM). Antibiofilm:bacteria: It also inhibited bacterial biofilm formation:S. mutans ( Shang D

Evidence 2 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Breast Cancer

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2009

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 41 µM

Target

Target Organism S. lactis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aureus, B. cereus, S. lactis (MIC 41 uM). Antibiofilm:bacteria: It also inhibited bacterial biofilm formation:S. mutans ( Shang D

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 41 µM

Target

Target Organism S. lactis

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against S. aureus, B. cereus, S. lactis (MIC 41 uM). Antibiofilm:bacteria: It also inhibited bacterial biofilm formation:S. mutans ( Shang D