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Peptide record

TPDB04173

Crot(1–9,38–42) NrTP1 Antibacterial Anticancer Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB04173
Crot(1–9,38–42) NrTP1
Antibacterial Anticancer Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CellPPD, and other sources, with an available 3D structural model.
Sequence
YKQCHKKGGKKGSG
Physicochemical Analysis
C64H108N22O18S1
ARNDEILMFPTWV
K
1505.76
10.48
6
0
1
+5
5.48
-1.957
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
98.95
4
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
0
E
1
Q
4
G
1
H
0
I
0
L
5
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 4 H: 1 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C64H108N22O18S1
1505.76
10.48
+5
5.48
-1.957
Free
L
Cationic
Linear
Free
Evidence Records 5 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Monomac6 Human Monocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
Cellular uptake slightly affected by CF-labelling
In vitro
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
>300 µM
Cytotoxic
IC50 | >300 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017
Evidence 4 Activity

Activity

IC50
Toxicity
300 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>300µM | Cytotoxicity: PBMC: IC50>300µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2008 Nov 27 51(22):7041-4.
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
Insights into the uptake mechanism of NrTP, a cell-penetrating peptide preferentially targeting the nucleolus of tumour cells
2012
Gandhi Rádis-Baptista et al. Chem Biol Drug Des. 2012 Jun 79(6):907-15.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human cervix epithelial carcinoma (HeLa), pancreatic adenocarcinoma (BxPC-3), ductal mammary gland carcinoma (BT-474) and murine neu roblastome (N2A)
Synthetic
Additional Detail Fields 1 fields
Human cervix epithelial carcinoma (HeLa), pancreatic adenocarcinoma (BxPC-3), ductal mammary gland carcinoma (BT-474) and murine neu roblastome (N2A)