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Peptide record

TPDB04152

Dhvar4 Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04152
Dhvar4
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP CPPsite3.0 APD_complete HemoPI PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRLFKKLLFSLRKY
Physicochemical Analysis
C90H150N24O17
ANDCEQGHIMPTWV
LK
1840.33
11.65
6
0
7
+6
0.27
-0.421
111.43
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
80.96
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
4
K
0
M
2
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 4 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C90H150N24O17
1840.33
11.65
+6
0.27
-0.421
Free
L
Cationic
Linear
Free
Evidence Records 40 records
Evidence 1 Activity

Activity

MIC
Antibacterial
250 µg/mL

Target

C.albicans 315 or B311 or resistant

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against fungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7
Evidence 2 Activity

Activity

MIC
Antibacterial
250 µg/mL

Target

C.glabrata 359

Source & Reference

dbAMP DRAMP

Other

Active against fungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807
Evidence 3 Activity

Activity

MIC
Antibacterial
62.5 µg/mL

Target

C. krusei 355

Source & Reference

dbAMP DRAMP

Other

ungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof
Evidence 4 Activity

Activity

MIC
Antibacterial
7.8 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP DRAMP

Other

esistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof et al., 2000 ). Also active against
Evidence 5 Activity

Activity

MIC
Antibacterial
250 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP DRAMP

Other

9 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof et al., 2000 ). Also active against prosthetic microorganisms, including C. t
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

9/6, S. mucilaginosus GB 16/3, E. faecium 603, E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

B 16/3, E. faecium 603, E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al
Evidence 9 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

ing et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 10 Activity

Activity

MIC
Antibacterial
16 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 11 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

ilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 12 Activity

Activity

MIC
Antifungal
250 µg/mL

Target

C.albicans 315 or B311 or resistant

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against fungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7
Evidence 13 Activity

Activity

MIC
Antifungal
250 µg/mL

Target

C.glabrata 359

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against fungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807
Evidence 14 Activity

Activity

MIC
Antifungal
62.5 µg/mL

Target

C. krusei 355

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof
Evidence 15 Activity

Activity

MIC
Antifungal
7.8 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

esistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof et al., 2000 ). Also active against
Evidence 16 Activity

Activity

MIC
Antifungal
250 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

9 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof et al., 2000 ). Also active against prosthetic microorganisms, including C. t
Evidence 17 Activity

Activity

MIC
Antifungal
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

9/6, S. mucilaginosus GB 16/3, E. faecium 603, E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16
Evidence 18 Activity

Activity

MIC
Antifungal
8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

B 16/3, E. faecium 603, E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (
Evidence 19 Activity

Activity

MIC
Antifungal
16 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al
Evidence 20 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ing et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 21 Activity

Activity

MIC
Antifungal
16 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 22 Activity

Activity

MIC
Antifungal
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 23 Activity

Activity

MIC
Antiparasitic
250 µg/mL

Target

C.albicans 315 or B311 or resistant

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against fungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7
Evidence 24 Activity

Activity

MIC
Antiparasitic
250 µg/mL

Target

C.glabrata 359

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against fungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807
Evidence 25 Activity

Activity

MIC
Antiparasitic
62.5 µg/mL

Target

C. krusei 355

Source & Reference

dbAMP 3.0 DRAMP

Other

ungi C.albicans 315 or B311 or resistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof
Evidence 26 Activity

Activity

MIC
Antiparasitic
7.8 µg/mL

Target

C. neoformans 316

Source & Reference

dbAMP 3.0 DRAMP

Other

esistant (MIC 250 ug/ml), C.glabrata 359 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof et al., 2000 ). Also active against
Evidence 27 Activity

Activity

MIC
Antiparasitic
250 µg/mL

Target

A.fumigatus X 807219

Source & Reference

dbAMP 3.0 DRAMP

Other

9 (MIC 250 ug/ml), C. krusei 355 (MIC 62.5 ug/ml), C. neoformans 316 (MIC 7.8 ug/ml), and A.fumigatus X 807219 (MIC 250 ug/ml) ( van't Hof et al., 2000 ). Also active against prosthetic microorganisms, including C. t
Evidence 28 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

9/6, S. mucilaginosus GB 16/3, E. faecium 603, E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16
Evidence 29 Activity

Activity

MIC
Antiparasitic
8 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

B 16/3, E. faecium 603, E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (
Evidence 30 Activity

Activity

MIC
Antiparasitic
16 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

E. coli at 4 ug/mL( Elving et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al
Evidence 31 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

ing et al., 2000 ). S. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 32 Activity

Activity

MIC
Antiparasitic
16 µM

Target

P. vulgaris

Source & Reference

dbAMP 3.0 DRAMP

Other

. aureus (MIC 16 uM), B. subtilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 33 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

ilis (MIC 8 uM), M. luteus (MIC 16 uM), E. coli (MIC 32 uM), P. vulgaris (MIC 16 uM), and P. aeruginosa (MIC 32 uM) ( Yang et al., 2023 .
Evidence 34 Activity

Activity

Cell-penetrating Peptides

Target

Monomac6 Human Monocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
Cellular uptake slightly affected by CF-labelling
In vitro
Evidence 35 Activity

Activity

50% Hemolysis
Toxicity
42±12 µM
Hemolytic Cytotoxic
50% Hemolysis | 42±12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 36 Activity

Activity

50% Hemolysis
Toxicity
58±2.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 58±2.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 37 Activity

Activity

50% Hemolysis
Toxicity
35±3.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 35±3.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 38 Activity

Activity

50% Hemolysis
Toxicity
23±2.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 23±2.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 39 Activity

Activity

50% Hemolysis
Toxicity
>109 µM
Hemolytic Cytotoxic
50% Hemolysis | >109 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides | FEBS Lett | 1999
Evidence 40 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.