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Peptide record

TPDB04150

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB04150
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
FLPFLKSILGKIL
Physicochemical Analysis
C76H125N15O15
ARNDCEQHMTWYV
L
1488.92
10.60
2
0
8
+2
-2.55
1.477
180.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
4
L
2
K
0
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 2 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C76H125N15O15
1488.92
10.60
+2
-2.55
1.477
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6-3.1 µM

Target

Staphylococcus aureus USA300

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
ed amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP

Other

this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

B. subtilis 168

Source & Reference

dbAMP

Other

ptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll H
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

A300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM (
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. glabrata

Source & Reference

dbAMP

Other

pidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM ( Mishra, Wang et al. 2018 )
Evidence 6 Activity

Activity

MIC
Antifungal
1.6-3.1 µM

Target

Staphylococcus aureus USA300

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
ed amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5
Evidence 7 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP CAFPdb Antifungipept

Other

this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM),
Evidence 8 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

B. subtilis 168

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll H
Evidence 9 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

A300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM (
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. glabrata

Source & Reference

dbAMP CAFPdb Antifungipept

Other

pidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM ( Mishra, Wang et al. 2018 )
Evidence 11 Activity

Activity

MIC
Antiparasitic
1.6-3.1 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

ed amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5
Evidence 12 Activity

Activity

MIC
Antiparasitic
1.6 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

NA

Other

this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM),
Evidence 13 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

B. subtilis 168

Source & Reference

NA

Other

ptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll H
Evidence 14 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Candida albicans

Source & Reference

NA

Other

A300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM (
Evidence 15 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

C. glabrata

Source & Reference

NA

Other

pidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM ( Mishra, Wang et al. 2018 )
Evidence 16 Activity

Activity

MIC
Antiviral
1.6-3.1 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

ed amount of material. We filled up this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5
Evidence 17 Activity

Activity

MIC
Antiviral
1.6 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

NA

Other

this gap by using a synthetic peptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM),
Evidence 18 Activity

Activity

MIC
Antiviral
12.5-25 µM

Target

B. subtilis 168

Source & Reference

NA

Other

ptide. Active against S. aureus USA300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll H
Evidence 19 Activity

Activity

MIC
Antiviral
12.5 µM

Target

Candida albicans

Source & Reference

NA

Other

A300 (MIC 1.6-3.1 uM), S. epidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM (
Evidence 20 Activity

Activity

MIC
Antiviral
12.5 µM

Target

C. glabrata

Source & Reference

NA

Other

pidermidis 1457 (MIC 1.6uM), B. subtilis 168 (MIC 12.5-25 uM), C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (1.6 uM). KIll HeLa cancer cells at 25 uM ( Mishra, Wang et al. 2018 )
Evidence 21 Activity

Activity

50% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
50% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins. | Peptides | 2018
Evidence 22 Activity

Activity

LC50
Toxicity
100 µM
Cytotoxic
LC50 | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins. | Peptides | 2018
Evidence 23 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.