TPDB

3D PDB MODEL

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TPDB ID TPDB04132

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

WNDTGKDADGSEY

FASTA

>TPDB04132|Antibacterial;Antifungal|length=13
WNDTGKDADGSEY

Formula C61H84N16O26

Absent Amino Acids RCQHILMFPV

Common Amino Acids D

Mass 1457.43

PI 3.50

Basic Residues 1

Acidic Residues 4

Hydrophobic Residues 3

Net Charge -3

Boman Index 4.45

Hydrophobicity -1.854

Aliphatic Index 7.69

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 479.61

Polar Residues 4

number

1

A

0

R

1

N

3

D

0

C

1

E

0

Q

2

G

0

H

0

I

0

L

1

K

0

M

0

F

0

P

1

S

1

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 3 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 0

Length

13

Formula

C61H84N16O26

Mass

1457.43

PI

3.50

Net Charge

-3

Boman Index

4.45

Hydrophobicity

-1.854

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.125-0.5 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Natural form is active against various Gram-positive bacteria S. aureus, S. faecalis, S. epidermidis (MIC 0.125-0.5 ug/ml), L. monocytogenes (MIC 4-16 ug/ml), S. pyogenes (MIC Updated 5/2019 Jan2020 7/2021 5/2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-16 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ious Gram-positive bacteria S. aureus, S. faecalis, S. epidermidis (MIC 0.125-0.5 ug/ml), L. monocytogenes (MIC 4-16 ug/ml), S. pyogenes (MIC Updated 5/2019 Jan2020 7/2021 5/2023

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.125-0.5 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Natural form is active against various Gram-positive bacteria S. aureus, S. faecalis, S. epidermidis (MIC 0.125-0.5 ug/ml), L. monocytogenes (MIC 4-16 ug/ml), S. pyogenes (MIC Updated 5/2019 Jan2020 7/2021 5/2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-16 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

ious Gram-positive bacteria S. aureus, S. faecalis, S. epidermidis (MIC 0.125-0.5 ug/ml), L. monocytogenes (MIC 4-16 ug/ml), S. pyogenes (MIC Updated 5/2019 Jan2020 7/2021 5/2023