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Peptide record

TPDB04037

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB04037
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
ILLKKLLKKI
Physicochemical Analysis
C60H116N14O11
ARNDCEQGHMFPSTWYV
LK
1209.67
11.00
4
0
6
+4
1.10
0.860
234.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C60H116N14O11
1209.67
11.00
+4
1.10
0.860
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>1000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stability. | J Antimicrob Chemother | 2016
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>500 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >500 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Designing α-helical peptides with enhanced synergism and selectivity against Mycobacterium smegmatis: Discerning the role of hydrophobicity and helicity. | Acta Biomater | 2015