TPDB

3D PDB MODEL

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TPDB ID TPDB03978

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

GLLWHLLH

FASTA

>TPDB03978|Antibacterial|length=8
GLLWHLLH

Formula C49H73N13O9

Absent Amino Acids ARNDCEQIKMFPSTYV

Common Amino Acids L

Mass 988.20

PI 8.00

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +0

Boman Index -2.16

Hydrophobicity 0.937

Aliphatic Index 195.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 556.57

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

2

H

0

I

4

L

0

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 4 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

8

Formula

C49H73N13O9

Mass

988.20

PI

8.00

Net Charge

+0

Boman Index

-2.16

Hydrophobicity

0.937

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 256 µg/mL

Target

Target Organism S.mutans UA159

Source & Reference

Database Source NA

Other

Evidence Text

Active against oral Cariogenic Bacteria: S.mutans UA159 (MIC 256 ug/ml), S.gordonii DL1 (MIC > 512 ug/ml), S.sanguinis ATCC10556 (MIC > 512 ug/ml), L.acidophilus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism L.acidophilus ATCC14931

Source & Reference

Database Source NA

Other

Evidence Text

IC 256 ug/ml), S.gordonii DL1 (MIC > 512 ug/ml), S.sanguinis ATCC10556 (MIC > 512 ug/ml), L.acidophilus ATCC14931 (MIC 128 ug/ml), L. casei ATCC393 (MIC 64 ug/ml), L.fermentium ATCC9338 (MIC 128 ug/ml), A. viscosus ATCC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism L. casei ATCC393

Source & Reference

Database Source NA

Other

Evidence Text

ug/ml), S.sanguinis ATCC10556 (MIC > 512 ug/ml), L.acidophilus ATCC14931 (MIC 128 ug/ml), L. casei ATCC393 (MIC 64 ug/ml), L.fermentium ATCC9338 (MIC 128 ug/ml), A. viscosus ATCC15987 (MIC 32 ug/ml), and A.naesl

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism L.fermentium ATCC9338

Source & Reference

Database Source NA

Other

Evidence Text

C > 512 ug/ml), L.acidophilus ATCC14931 (MIC 128 ug/ml), L. casei ATCC393 (MIC 64 ug/ml), L.fermentium ATCC9338 (MIC 128 ug/ml), A. viscosus ATCC15987 (MIC 32 ug/ml), and A.naeslundii ATCC12104 (MIC 128 ug/ml). Warnin

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism A. viscosus ATCC15987

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 128 ug/ml), L. casei ATCC393 (MIC 64 ug/ml), L.fermentium ATCC9338 (MIC 128 ug/ml), A. viscosus ATCC15987 (MIC 32 ug/ml), and A.naeslundii ATCC12104 (MIC 128 ug/ml). Warning: other bacteria not tested (Gram-).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism A.naeslundii ATCC12104

Source & Reference

Database Source NA

Other

Evidence Text

ug/ml), L.fermentium ATCC9338 (MIC 128 ug/ml), A. viscosus ATCC15987 (MIC 32 ug/ml), and A.naeslundii ATCC12104 (MIC 128 ug/ml). Warning: other bacteria not tested (Gram-).