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Peptide record

TPDB03968

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB03968
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifp Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI PD_Hemolysis
standard
No
A 44-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GKVWDWIKSAAKKIWSSEPVSQLKGQVLNAAKNYVAEKIGATPT
Physicochemical Analysis
C220H350N58O62
RCHMF
K
4799.55
10.27
7
3
19
+4
6.65
-0.366
84.32
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17990
374.83
11
Residue Composition
number
6
A
0
R
2
N
1
D
0
C
2
E
2
Q
3
G
0
H
3
I
2
L
7
K
0
M
0
F
2
P
4
S
2
T
3
W
1
Y
4
V
Amino Acid Distribution
A: 6 R: 0 N: 2 D: 1 C: 0 E: 2 Q: 2 G: 3 H: 0 I: 3 L: 2 K: 7 M: 0 F: 0 P: 2 S: 4 T: 2 W: 3 Y: 1 V: 4
Chemical Descriptors
44
C220H350N58O62
4799.55
10.27
+4
6.65
-0.366
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20.8 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E.
Evidence 2 Activity

Activity

MIC
Antibacterial
5.2 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast
Evidence 3 Activity

Activity

MIC
Antibacterial
5.2 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
2.6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
1.3 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
20.8 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E.
Evidence 7 Activity

Activity

MIC
Antifungal
5.2 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast
Evidence 8 Activity

Activity

MIC
Antifungal
5.2 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
2.6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
1.3 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
20.8 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E.
Evidence 12 Activity

Activity

MIC
Antiparasitic
5.2 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast
Evidence 13 Activity

Activity

MIC
Antiparasitic
5.2 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

Gram- P-aeruginosa (MIC >20.8 uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 14 Activity

Activity

MIC
Antiparasitic
2.6 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

uM), E. coli (MIC 20.8 uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
1.3 µM

Target

Enterococcus faecalis

Source & Reference

DRAMP

Other

uM), Gram+ B. subtilis (MIC 5.2 uM), S. epidermidis (MIC 5.2 uM), S. aureus (MIC 2.6 uM), E. faecalis (MIC 1.3 uM), and yeast C-albicans (MIC >20.8 uM).
Evidence 16 Activity

Activity

1% Hemolysis
Toxicity
44.5 µM
Hemolytic Cytotoxic
1% Hemolysis | 44.5 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. | Biochem J | 2001
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
2.7 µM
Hemolytic Cytotoxic
0% Hemolysis | 2.7 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. | Biochem J | 2001
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.