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Peptide record

TPDB03963

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB03963
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP AVPpred-BWR dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVIPCGESCVFIPCISTLLGCSCKNKVCYRN
Physicochemical Analysis
C141H232N38O41S6
ADQHMW
C
3307.98
8.02
3
1
10
+2
1.76
0.642
90.97
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
56.38
13
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
1
E
0
Q
3
G
0
H
3
I
2
L
2
K
0
M
1
F
2
P
3
S
1
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 2 K: 2 M: 0 F: 1 P: 2 S: 3 T: 1 W: 0 Y: 1 V: 3
Chemical Descriptors
31
C141H232N38O41S6
3307.98
8.02
+2
1.76
0.642
Evidence Records 36 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.41 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S.
Evidence 2 Activity

Activity

MIC
Antibacterial
25.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.lute
Evidence 3 Activity

Activity

MIC
Antibacterial
6.8 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 4 Activity

Activity

MIC
Antibacterial
8.2 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP DRAMP

Other

ainst Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
13.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

M), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tro
Evidence 6 Activity

Activity

MIC
Antibacterial
>500 µM

Target

M.luteus

Source & Reference

dbAMP DRAMP

Other

.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (S
Evidence 7 Activity

Activity

MIC
Antibacterial
29 µM

Target

C. kefyr

Source & Reference

dbAMP DRAMP

Other

, Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 8 Activity

Activity

MIC
Antibacterial
>500 µM

Target

C.tropicalis

Source & Reference

dbAMP DRAMP

Other

5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 9 Activity

Activity

MIC
Antifungal
0.41 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S.
Evidence 10 Activity

Activity

MIC
Antifungal
25.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.lute
Evidence 11 Activity

Activity

MIC
Antifungal
6.8 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 12 Activity

Activity

MIC
Antifungal
8.2 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 13 Activity

Activity

MIC
Antifungal
13.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tro
Evidence 14 Activity

Activity

MIC
Antifungal
>500 µM

Target

M.luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (S
Evidence 15 Activity

Activity

MIC
Antifungal
29 µM

Target

C. kefyr

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 16 Activity

Activity

MIC
Antifungal
>500 µM

Target

C.tropicalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 17 Activity

Activity

MIC
Antiparasitic
0.41 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S.
Evidence 18 Activity

Activity

MIC
Antiparasitic
25.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.lute
Evidence 19 Activity

Activity

MIC
Antiparasitic
6.8 µM

Target

P. vulgaris

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 20 Activity

Activity

MIC
Antiparasitic
8.2 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP 3.0 DRAMP

Other

ainst Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 21 Activity

Activity

MIC
Antiparasitic
13.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

M), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tro
Evidence 22 Activity

Activity

MIC
Antiparasitic
>500 µM

Target

M.luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (S
Evidence 23 Activity

Activity

MIC
Antiparasitic
29 µM

Target

C. kefyr

Source & Reference

dbAMP 3.0 DRAMP

Other

, Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 24 Activity

Activity

MIC
Antiparasitic
>500 µM

Target

C.tropicalis

Source & Reference

dbAMP 3.0 DRAMP

Other

5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 25 Activity

Activity

MIC
Antiviral
0.41 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S.
Evidence 26 Activity

Activity

MIC
Antiviral
25.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.lute
Evidence 27 Activity

Activity

MIC
Antiviral
6.8 µM

Target

P. vulgaris

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 28 Activity

Activity

MIC
Antiviral
8.2 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ainst Gram- E. coli (MIC 0.41 uM), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 29 Activity

Activity

MIC
Antiviral
13.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

M), P. aeruginosa (MIC 25.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tro
Evidence 30 Activity

Activity

MIC
Antiviral
>500 µM

Target

M.luteus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

.5 uM), P. vulgaris (MIC 6.8 uM), K. oxytoca (MIC 8.2 uM), Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (S
Evidence 31 Activity

Activity

MIC
Antiviral
29 µM

Target

C. kefyr

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

, Gram+ S. aureus (MIC 13.5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 32 Activity

Activity

MIC
Antiviral
>500 µM

Target

C.tropicalis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

5 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 29 uM), and C.tropicalis (MIC >500 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 33 Activity

Activity

50% Hemolysis
Toxicity
550 µM
Hemolytic Cytotoxic
50% Hemolysis | 550 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. | Proc Natl Acad Sci U S A | 1999
Evidence 34 Activity

Activity

IC50
Toxicity
820 µM
Cytotoxic
IC50 | 820 | µM | target cell: Mouse fibroblasts

Target

Mouse fibroblasts

Source & Reference

NA
DBAASP
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. | Proc Natl Acad Sci U S A | 1999
Evidence 35 Activity

Activity

IC50
Toxicity
0.5 µM
Cytotoxic
IC50 | 0.5 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Cyclotides as natural anti-HIV agents | Biopolymers | 2008
Evidence 36 Activity

Activity

EC50
Toxicity
550 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.10430870] EC50 = 550 µM against blood type A human erythrocytes. | Cytotoxicity: [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 820 µM.##[Ref.18008336]CEM-SS cells:IC50=500 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Proc Natl Acad Sci U S A. 1999 Aug 3 96(16):8913-8918.##Biopolymers. 2008 90(1):51-60.##Biochem Biophys Res Commun. 1996 Nov 12 228(2):632-8. doi: 10.1006/bbrc.1996.1708.