TPDB

3D PDB MODEL

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TPDB ID TPDB03948

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.

Sequence

FLGAIAQALTSLLGKL

FASTA

>TPDB03948|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=16
FLGAIAQALTSLLGKL

Formula C76H130N18O20

Absent Amino Acids RNDCEHMPWYV

Common Amino Acids L

Mass 1615.98

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +1

Boman Index -2.89

Hydrophobicity 1.375

Aliphatic Index 165.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

3

A

0

R

0

N

0

D

0

C

0

E

1

Q

2

G

0

H

1

I

5

L

1

K

0

M

1

F

0

P

1

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 5 K: 1 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

16

Formula

C76H130N18O20

Mass

1615.98

PI

10.10

Net Charge

+1

Boman Index

-2.89

Hydrophobicity

1.375

Evidence 1 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 22 µM

Hemolysis Raw

mouse erythrocytes: LC50=22 µM

Target

RBC Target mouse erythrocytes

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

J Pept Sci. 2017 Oct 23(10):769-776.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 22 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 22 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae). | J Pept Sci | 2017

Evidence 3 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 22 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: mouse erythrocytes: LC50=22 µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Pept Sci. 2017 Oct 23(10):769-776.

Evidence 4 Hemolysis

Activity

Activity Measurement 22 µM

Activity Endpoint LC50

Hemolysis Raw

mouse erythrocytes: LC50=22 µM

Detail Source Activity Hemolysis

Target

RBC Target mouse erythrocytes

Source & Reference

source PD_Hemolysis

Reference

J Pept Sci. 2017 Oct 23(10):769-776.

Source DRAMP4

Database Source PD_Hemolysis