Back to search

Peptide record

TPDB03935

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB03935
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb dbACP Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC
Physicochemical Analysis
C147H254N40O42S2
RHIMPTWY
G
3318.00
9.65
5
2
13
+3
4.74
0.470
117.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.77
6
Residue Composition
number
1
A
0
R
1
N
1
D
2
C
1
E
1
Q
7
G
0
H
0
I
6
L
5
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 2 E: 1 Q: 1 G: 7 H: 0 I: 0 L: 6 K: 5 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 5
Chemical Descriptors
33
C147H254N40O42S2
3318.00
9.65
+3
4.74
0.470
Evidence Records 42 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.9 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dyse
Evidence 2 Activity

Activity

MIC
Antibacterial
9.0 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E
Evidence 3 Activity

Activity

MIC
Antibacterial
15.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pne
Evidence 4 Activity

Activity

MIC
Antibacterial
18.1 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabi
Evidence 5 Activity

Activity

MIC
Antibacterial
18.1 µM

Target

S. dysenteriae

Source & Reference

dbAMP DRAMP

Other

1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aerugi
Evidence 6 Activity

Activity

MIC
Antibacterial
4.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 7 Activity

Activity

MIC
Antibacterial
4.5 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC
Evidence 9 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5
Evidence 10 Activity

Activity

MIC
Antibacterial
37.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cance
Evidence 11 Activity

Activity

MIC
Antibacterial
37.5 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

(MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and He
Evidence 12 Activity

Activity

MIC
Antibacterial
37.5 µM

Target

S. lactis

Source & Reference

dbAMP DRAMP

Other

ans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 ~50 uM).
Evidence 13 Activity

Activity

MIC
Antibacterial
50 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

ve against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 ~50 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
1.9 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dyse
Evidence 15 Activity

Activity

MIC
Antifungal
9.0 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E
Evidence 16 Activity

Activity

MIC
Antifungal
15.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pne
Evidence 17 Activity

Activity

MIC
Antifungal
18.1 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabi
Evidence 18 Activity

Activity

MIC
Antifungal
18.1 µM

Target

S. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aerugi
Evidence 19 Activity

Activity

MIC
Antifungal
4.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 20 Activity

Activity

MIC
Antifungal
4.5 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/
Evidence 21 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC
Evidence 22 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5
Evidence 23 Activity

Activity

MIC
Antifungal
37.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cance
Evidence 24 Activity

Activity

MIC
Antifungal
37.5 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and He
Evidence 25 Activity

Activity

MIC
Antifungal
37.5 µM

Target

S. lactis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 ~50 uM).
Evidence 26 Activity

Activity

MIC
Antifungal
50 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ve against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 ~50 uM).
Evidence 27 Activity

Activity

MIC
Antiparasitic
1.9 µM

Target

M. luteus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dyse
Evidence 28 Activity

Activity

MIC
Antiparasitic
9.0 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E
Evidence 29 Activity

Activity

MIC
Antiparasitic
15.1 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pne
Evidence 30 Activity

Activity

MIC
Antiparasitic
18.1 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabi
Evidence 31 Activity

Activity

MIC
Antiparasitic
18.1 µM

Target

S. dysenteriae

Source & Reference

DRAMP

Other

1.9 uM), S. aureus (MIC 9.0 uM), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aerugi
Evidence 32 Activity

Activity

MIC
Antiparasitic
4.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

), B. subtilis (MIC 15.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 33 Activity

Activity

MIC
Antiparasitic
4.5 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

.1 uM), S. epidermidis (MIC 18.1 uM), S. dysenteriae (MIC 18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/
Evidence 34 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

P.aeruginosa

Source & Reference

DRAMP

Other

18.1 uM), E. coli (MIC 4.5 uM), K. pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC
Evidence 35 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

pneumoniae (MIC 4.5 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5
Evidence 36 Activity

Activity

MIC
Antiparasitic
37.5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cance
Evidence 37 Activity

Activity

MIC
Antiparasitic
37.5 µM

Target

B. cereus

Source & Reference

DRAMP

Other

(MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and He
Evidence 38 Activity

Activity

MIC
Antiparasitic
37.5 µM

Target

S. lactis

Source & Reference

DRAMP

Other

ans (MIC 100 ug/ml). Active against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 ~50 uM).
Evidence 39 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

ve against S. aureus (MIC 37.5 uM), B. cereus (MIC 37.5 uM), and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 ~50 uM).
Evidence 40 Activity

Activity

2% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. | Peptides | 2007
Evidence 41 Activity

Activity

50% Hemolysis
Toxicity
65.2±7.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 65.2±7.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata. | World J Microbiol Biotechnol | 2013
Evidence 42 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:17698251] It has 1.86% hemolytic activity at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 2007 28: 1532-1539.