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Peptide record

TPDB03934

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB03934

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FWGALAKGALKLIPSLFSSFSKKD

FASTA

>TPDB03934|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=24
FWGALAKGALKLIPSLFSSFSKKD

Formula C126H195N29O31

Absent Amino Acids RNCEQHMTYV

Common Amino Acids LKS

Mass 2612.11

PI 10.55

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +3

Boman Index -2.12

Hydrophobicity 0.329

Aliphatic Index 93.75

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 210.56

Polar Residues 4

number

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 4 K: 4 M: 0 F: 3 P: 1 S: 4 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C126H195N29O31

Mass

2612.11

10.55

Net Charge

Boman Index

-2.12

Hydrophobicity

0.329

Evidence 1 Activity

Activity

Detail Source Activity Hemolysis

Hemolysis Raw

[Ref.11563967]Strong hemolytic activity (11.1-44.5 microM) against sheep erythrocytes

Target

RBC Target sheep erythrocytes

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Biochem J. 2001 Oct 1 359(Pt 1):35-45.##Biochim Biophys Acta. 2004 Aug 30 1664(2):182-188.##Biophys J. 2004 Oct 87(4):2497-507.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 91% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 44.5 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

91% Hemolysis | 44.5 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. | Biochem J | 2001

Evidence 3 Activity

Activity

Activity Endpoint 18% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 11.1 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

18% Hemolysis | 11.1 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. | Biochem J | 2001

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 3.3 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 3.3 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 5 Activity

Activity

Activity Endpoint 51% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 22.2 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

51% Hemolysis | 22.2 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. | Biochem J | 2001

Evidence 6 Activity

Activity

Activity Endpoint 4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 5.5 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

4% Hemolysis | 5.5 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. | Biochem J | 2001

Evidence 7 Activity

Activity

Activity Endpoint 1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2.7 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1% Hemolysis | 2.7 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. | Biochem J | 2001

Evidence 8 Activity

Activity

Activity Endpoint 80% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

80% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Improved protease stability of the antimicrobial peptide Pin2 substituted with D-amino acids. | Protein J | 2013

Evidence 9 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.11563967]Strong hemolytic activity (11.1-44.5 microM) against sheep erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochem J. 2001 Oct 1 359(Pt 1):35-45.##Biochim Biophys Acta. 2004 Aug 30 1664(2):182-188.##Biophys J. 2004 Oct 87(4):2497-507.

Evidence 10 Hemolysis

Activity

Hemolysis Raw

[Ref.11563967]Strong hemolytic activity (11.1-44.5 microM) against sheep erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target sheep erythrocytes

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Reference

Biochem J. 2001 Oct 1 359(Pt 1):35-45.##Biochim Biophys Acta. 2004 Aug 30 1664(2):182-188.##Biophys J. 2004 Oct 87(4):2497-507.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.