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Peptide record

TPDB03929

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB03929
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILDAIKAIAKAAG
Physicochemical Analysis
C59H106N16O17
RNCEQHMFPSTWYV
A
1311.59
9.88
2
1
9
+1
0.89
1.014
147.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
5
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
3
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C59H106N16O17
1311.59
9.88
+1
0.89
1.014
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.1-8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
48.8-64 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
24.4-32 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

ainst S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
6.1-8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
48.8-64 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
24.4-32 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
6.1-8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
48.8-64 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
24.4-32 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

ainst S. aureus ATCC 25923 (MIC 6.1-8 uM), P. aeruginosa ATCC 27853 (MIC 48.8-64 uM), and E. coli ATCC 25922 (MIC 24.4-32 uM).
Evidence 10 Activity

Activity

5% Hemolysis
Toxicity
195.2 µM
Hemolytic Cytotoxic
5% Hemolysis | 195.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 11 Activity

Activity

% Hemolysis
Toxicity
4.7 %
Hemolytic
Hemolytic_activity: [Ref.14715660] HSP1 MIC concentration (256 µg/mL = 195.2 µM) produced 4.7% hemolysis against human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2004 Mar 26 279(13):13018-13026. ##Biochim Biophys Acta Biomembr . 2021 Jan 1 1863(1):183449. doi: 10.1016/j.bbamem.2020.183449. Epub 2020 Aug 21.