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Peptide record

TPDB03925

Citropin 11 Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Neuropeptide Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB03925
Citropin 11
Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides Neuroactive peptides
Peptipedia AntiBP3 dbAMP DRAMP ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
GLFDVIKKVASVIGGL
Physicochemical Analysis
C76H130N18O20
RNCEQHMPTWY
GV
1615.98
9.88
2
1
9
+1
0.54
1.281
158.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
0
H
2
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
16
C76H130N18O20
1615.98
9.88
+1
0.54
1.281
Evidence Records 77 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3-6 µg/mL

Target

L. lactis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epide
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml),
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.multocida

Source & Reference

dbAMP DRAMP

Other

Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml),
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml),
Evidence 5 Activity

Activity

MIC
Antibacterial
12-25 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

L. innocua

Source & Reference

dbAMP DRAMP

Other

P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml),
Evidence 7 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

S. uberis

Source & Reference

dbAMP DRAMP

Other

, M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml
Evidence 8 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP

Other

, S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml
Evidence 9 Activity

Activity

MIC
Antibacterial
25-50 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

, L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012
Evidence 10 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

L. innocua

Source & Reference

dbAMP DRAMP

Other

S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gra
Evidence 11 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

reus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug
Evidence 12 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP DRAMP

Other

nd B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gr
Evidence 13 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP DRAMP

Other

abrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml
Evidence 14 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP DRAMP

Other

t Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/m
Evidence 15 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP DRAMP

Other

aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi
Evidence 16 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP DRAMP

Other

. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albi
Evidence 17 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

P.aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP

Other

am- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 18 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

dbAMP DRAMP

Other

, K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neuba
Evidence 19 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP DRAMP

Other

ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neubauer et al., 2017 ). Inhibited Escherich
Evidence 20 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP DRAMP

Other

ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neubauer et al., 2017 ). Inhibited Escherichia coli ATP synthase ( Laughlin and Ahmad,
Evidence 21 Activity

Activity

MIC
Antifungal
3-6 µg/mL

Target

L. lactis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epide
Evidence 22 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml),
Evidence 23 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.multocida

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml),
Evidence 24 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml),
Evidence 25 Activity

Activity

MIC
Antifungal
12-25 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml),
Evidence 26 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

L. innocua

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml),
Evidence 27 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

S. uberis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml
Evidence 28 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml
Evidence 29 Activity

Activity

MIC
Antifungal
25-50 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012
Evidence 30 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

L. innocua

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gra
Evidence 31 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

reus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug
Evidence 32 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nd B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gr
Evidence 33 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

abrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml
Evidence 34 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/m
Evidence 35 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi
Evidence 36 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albi
Evidence 37 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

P.aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

am- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 38 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neuba
Evidence 39 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neubauer et al., 2017 ). Inhibited Escherich
Evidence 40 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neubauer et al., 2017 ). Inhibited Escherichia coli ATP synthase ( Laughlin and Ahmad,
Evidence 41 Activity

Activity

MIC
Antiparasitic
3-6 µg/mL

Target

L. lactis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epide
Evidence 42 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

E.coli

Source & Reference

DRAMP

Other

Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml),
Evidence 43 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

P.multocida

Source & Reference

DRAMP

Other

Active against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml),
Evidence 44 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

M. luteus

Source & Reference

DRAMP

Other

against L. lactis (MIC 3-6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml),
Evidence 45 Activity

Activity

MIC
Antiparasitic
12-25 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

6 ug/ml), E.coli (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml),
Evidence 46 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

L. innocua

Source & Reference

DRAMP

Other

P.multocida (MIC>100 ug/ml), M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml),
Evidence 47 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

S. uberis

Source & Reference

DRAMP

Other

, M. luteus (MIC 25 ug/ml), S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml
Evidence 48 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

DRAMP

Other

, S. epidermidis (MIC 12-25 ug/ml), L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml
Evidence 49 Activity

Activity

MIC
Antiparasitic
25-50 µg/mL

Target

B. cereus

Source & Reference

DRAMP

Other

, L. innocua (MIC 100 ug/ml), S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012
Evidence 50 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

L. innocua

Source & Reference

DRAMP

Other

S. uberis (MIC 12 ug/ml), S. aureus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gra
Evidence 51 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

reus or MRSA (MIC 25 ug/ml), B. cereus (MIC 25-50 ug/ml), L. innocua (MIC 100 ug/ml), and B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug
Evidence 52 Activity

Activity

MIC
Antiparasitic
32 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

DRAMP

Other

nd B. subtilis (MIC 12.5 ug/ml) ( Calabrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gr
Evidence 53 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

DRAMP

Other

abrese AN et al., 2012 ). Also, active against Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml
Evidence 54 Activity

Activity

MIC
Antiparasitic
32 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

DRAMP

Other

t Gram+ E. faecalis PCM 2673 (MIC 32 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/m
Evidence 55 Activity

Activity

MIC
Antiparasitic
32 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

DRAMP

Other

aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi
Evidence 56 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

DRAMP

Other

. pneumoniae ATCC 49619 (MIC 32 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albi
Evidence 57 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

P.aeruginosa ATCC 9027

Source & Reference

DRAMP

Other

am- E. coli ATCC 25922 or 23506 (MIC 32 ug/ml), K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 58 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

DRAMP

Other

, K. pneumoniae ATCC 700603 (MIC 16 ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neuba
Evidence 59 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

DRAMP

Other

ug/ml), P.aeruginosa ATCC 9027 (MIC 128 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neubauer et al., 2017 ). Inhibited Escherich
Evidence 60 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

DRAMP

Other

ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml) ( Neubauer et al., 2017 ). Inhibited Escherichia coli ATP synthase ( Laughlin and Ahmad,
Evidence 61 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Litoria lesueurii
Evidence 62 Activity

Activity

50% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
50% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of alpha-helical antimicrobial peptides: do's and don'ts. | Chembiochem | 2015
Evidence 63 Activity

Activity

0% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017
Evidence 64 Activity

Activity

5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017
Evidence 65 Activity

Activity

IC50
Toxicity
3.02 µg/mL
Cytotoxic
IC50 | 3.02 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii. | Probiotics Antimicrob Proteins | 2018
Evidence 66 Activity

Activity

16.5±3% Hemolysis
Toxicity
34 µM
Hemolytic Cytotoxic
16.5±3% Hemolysis | 34 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Antibiofilm Activities of Helical Antimicrobial Peptide Sequences Incorporating Metal-Binding Motifs. | Biochemistry | 2019
Evidence 67 Activity

Activity

1% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
1% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis. | Int J Antimicrob Agents | 2010
Evidence 68 Activity

Activity

50% Hemolysis
Toxicity
>32 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity. | Peptides | 2019
Evidence 69 Activity

Activity

IC50
Toxicity
20.98 µg/mL
Cytotoxic
IC50 | 20.98 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity. | Peptides | 2019
Evidence 70 Activity

Activity

IC50
Toxicity
63.0 µM
Cytotoxic
IC50 | 63.0 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
The design and anticancer activity of a citropin1.1 hybrid peptide with selective activity against highly invasive metastatic cell lines. | Int J Res Pharm Sci | 2019
Evidence 71 Activity

Activity

IC50
Toxicity
60.9 µM
Cytotoxic
IC50 | 60.9 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
The design and anticancer activity of a citropin1.1 hybrid peptide with selective activity against highly invasive metastatic cell lines. | Int J Res Pharm Sci | 2019
Evidence 72 Activity

Activity

86.3% Hemolysis
Toxicity
90 µM
Hemolytic Cytotoxic
86.3% Hemolysis | 90 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design and anticancer activity of a citropin1.1 hybrid peptide with selective activity against highly invasive metastatic cell lines. | Int J Res Pharm Sci | 2019
Evidence 73 Activity

Activity

55.1% Hemolysis
Toxicity
70 µM
Hemolytic Cytotoxic
55.1% Hemolysis | 70 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design and anticancer activity of a citropin1.1 hybrid peptide with selective activity against highly invasive metastatic cell lines. | Int J Res Pharm Sci | 2019
Evidence 74 Activity

Activity

33.7% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
33.7% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design and anticancer activity of a citropin1.1 hybrid peptide with selective activity against highly invasive metastatic cell lines. | Int J Res Pharm Sci | 2019
Evidence 75 Activity

Activity

19.8% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
19.8% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design and anticancer activity of a citropin1.1 hybrid peptide with selective activity against highly invasive metastatic cell lines. | Int J Res Pharm Sci | 2019
Evidence 76 Activity

Activity

7.2% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
7.2% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design and anticancer activity of a citropin1.1 hybrid peptide with selective activity against highly invasive metastatic cell lines. | Int J Res Pharm Sci | 2019
Evidence 77 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.