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Peptide record

TPDB03920

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB03920
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 dbACP iACP-DRLF Antifungipept CAFPdb i2APP APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
INWLKLGKAIIDAL
Physicochemical Analysis
C75H126N18O18
RCEQHMFPSTYV
IL
1567.94
9.88
2
1
9
+1
-1.16
0.886
181.43
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
350.78
1
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
0
Q
1
G
0
H
3
I
3
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C75H126N18O18
1567.94
9.88
+1
-1.16
0.886
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
120 µM

Target

S.aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
poorly active against S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.
Evidence 2 Activity

Activity

MIC
Antibacterial
164 µM

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

poorly active against S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.2 uM). Agelaia-MPI showed a
Evidence 3 Activity

Activity

MIC
Antibacterial
3.1-6.2 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP

Other

st S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.2 uM). Agelaia-MPI showed adhesion inhibition for isolates AB 02 at a concentration of 25 uM wh
Evidence 4 Activity

Activity

MIC
Antifungal
120 µM

Target

S.aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
poorly active against S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.
Evidence 5 Activity

Activity

MIC
Antifungal
164 µM

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

poorly active against S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.2 uM). Agelaia-MPI showed a
Evidence 6 Activity

Activity

MIC
Antifungal
3.1-6.2 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

st S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.2 uM). Agelaia-MPI showed adhesion inhibition for isolates AB 02 at a concentration of 25 uM wh
Evidence 7 Activity

Activity

MIC
Antiparasitic
120 µM

Target

S.aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
poorly active against S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.
Evidence 8 Activity

Activity

MIC
Antiparasitic
164 µM

Target

P.aeruginosa

Source & Reference

DRAMP

Other

poorly active against S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.2 uM). Agelaia-MPI showed a
Evidence 9 Activity

Activity

MIC
Antiparasitic
3.1-6.2 µM

Target

A. baumannii

Source & Reference

DRAMP

Other

st S.aureus (MIC 120 uM), P.aeruginosa (MIC 164 uM), and E.coli 240 uM (ref. see AP1640), A. baumannii (MIC 3.1-6.2 uM). Agelaia-MPI showed adhesion inhibition for isolates AB 02 at a concentration of 25 uM wh
Evidence 10 Activity

Activity

% Hemolysis
Hemolysis
70 %
[Ref.15225564]70% hemolytic activity at 156 ng/ml against rat erythrocytes

Target

rat erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxicon. 2004 Jul 44(1):67-74.##Rapid Commun Mass Spectrom. 2004 18(6):636-642.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

70% Hemolysis
Toxicity
0.156 µg/mL
Hemolytic Cytotoxic
70% Hemolysis | 0.156 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes. | Toxicon | 2004
Evidence 12 Activity

Activity

57% degranulation
Toxicity
1.56 µg/mL
Cytotoxic
57% degranulation | 1.56 | µg/mL | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes. | Toxicon | 2004
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
11.5±1.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 11.5±1.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus. | Chembiochem | 2020
Evidence 14 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.15225564]70% hemolytic activity at 156 ng/ml against rat erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2004 Jul 44(1):67-74.##Rapid Commun Mass Spectrom. 2004 18(6):636-642.
Evidence 15 Hemolysis

Activity

70 %
% Hemolysis
[Ref.15225564]70% hemolytic activity at 156 ng/ml against rat erythrocytes
Hemolysis

Target

rat erythrocytes

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Toxicon. 2004 Jul 44(1):67-74.##Rapid Commun Mass Spectrom. 2004 18(6):636-642.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.