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Peptide record

TPDB03919

Chassatide C4 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB03919
Chassatide C4
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GDACGETCFTGICFTAGCSCNPWPTCTRN
Physicochemical Analysis
C123H183N35O42S6
QHLKMYV
C
3016.38
4.07
1
2
6
-1
0.47
0.007
20.34
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
194.77
14
Residue Composition
number
2
A
1
R
2
N
1
D
6
C
1
E
0
Q
4
G
0
H
1
I
0
L
0
K
0
M
2
F
2
P
1
S
5
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 0 K: 0 M: 0 F: 2 P: 2 S: 1 T: 5 W: 1 Y: 0 V: 0
Chemical Descriptors
29
C123H183N35O42S6
3016.38
4.07
-1
0.47
0.007
Free
L
Not Available
Free
Antibacterial
Chassalia chartacea
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
TOXIC TO HeLa cells.
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
TOXIC TO HeLa cells.
Evidence 4 Activity

Activity

HD50
Hemolysis
51.9 µM
[Ref.22467870] HD50=51.9 µM against human type A red blood cells.

Target

human type A red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2012 May 18 287(21):17598-17607.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
51.9 µM
Hemolytic Cytotoxic
50% Hemolysis | 51.9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. | J Biol Chem | 2012
Evidence 6 Activity

Activity

HD50
Toxicity
51.9 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.22467870] HD50=51.9 µM against human type A red blood cells. | Cytotoxicity: [Ref.22467870] Cytotoxicity: HeLa cells (IC50=9.8 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2012 May 18 287(21):17598-17607.
Evidence 7 Hemolysis

Activity

51.9 µM
HD50
[Ref.22467870] HD50=51.9 µM against human type A red blood cells.
Hemolysis

Target

human type A red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2012 May 18 287(21):17598-17607.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.