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Peptide record

TPDB03918

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB03918
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 SATPdb dbACP iACP-DRLF Antifungipept AI4AVP AVPpred-BWR dbAMP 3.0 DRAMP DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
GLPICGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
C117H187N35O40S6
ADQHKMFY
C
2916.34
5.90
1
1
5
-0
1.87
0.159
46.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
201.45
14
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
1
E
0
Q
5
G
0
H
1
I
1
L
0
K
0
M
0
F
3
P
2
S
4
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 3 S: 2 T: 4 W: 1 Y: 0 V: 2
Chemical Descriptors
29
C117H187N35O40S6
2916.34
5.90
-0
1.87
0.159
Evidence Records 9 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 350 nM) and cytotoxicity (TC50 >3500 nM), therapeutic index (11) (Ireland et al., 2008) . Updated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

DRAMP Antifungipept

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 350 nM) and cytotoxicity (TC50 >3500 nM), therapeutic index (11) (Ireland et al., 2008) . Updated 7/2021
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 350 nM) and cytotoxicity (TC50 >3500 nM), therapeutic index (11) (Ireland et al., 2008) . Updated 7/2021
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 350 nM) and cytotoxicity (TC50 >3500 nM), therapeutic index (11) (Ireland et al., 2008) . Updated 7/2021
Evidence 5 Activity

Activity

HD50
Hemolysis
6.96 µM
[Ref.20580652] HD50=6.96µM against human type O red blood cells.

Target

human type O red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Biopolymers. 2008 90(1):51-60.##J Nat Prod. 1999 Feb 62(2):283-286.##J Nat Prod. 2004 Feb 67(2):144-147.##Peptides. 2010 Aug 31(8):1434-40.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
6.96 µM
Hemolytic Cytotoxic
50% Hemolysis | 6.96 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterization of cytotoxic cyclotides from Viola tricolor. | Peptides | 2010
Evidence 7 Activity

Activity

IC50
Toxicity
4.0 µM
Cytotoxic
IC50 | 4.0 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. | J Nat Prod | 2008
Evidence 8 Activity

Activity

HD50
Toxicity
6.96 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20580652] HD50=6.96µM against human type O red blood cells. | Cytotoxicity: [Ref.20580652] Cytotoxicity: U251(IC50=38.84µg/mL), MDA-MB-231(IC50>10µg/mL), A549(IC50>10µg/mL), DU145(IC50>10µg/mL), BEL-7402(IC50>10µg/mL).##[Ref.14987049] Cytotoxicity: U-937 GTB (lymphoma)(IC50 = 4 µM) and RPMI-8226/s (myeloma)(IC50 = 4 µM).##[Ref.18008336]CEM-SS cells:IC50=3980 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biopolymers. 2008 90(1):51-60.##J Nat Prod. 1999 Feb 62(2):283-286.##J Nat Prod. 2004 Feb 67(2):144-147.##Peptides. 2010 Aug 31(8):1434-40.
Evidence 9 Hemolysis

Activity

6.96 µM
HD50
[Ref.20580652] HD50=6.96µM against human type O red blood cells.
Hemolysis

Target

human type O red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Biopolymers. 2008 90(1):51-60.##J Nat Prod. 1999 Feb 62(2):283-286.##J Nat Prod. 2004 Feb 67(2):144-147.##Peptides. 2010 Aug 31(8):1434-40.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.