Peptide record

TPDB03917

Alpha-melanocyte-stimulating hormone d-Alpha-MSH Melanocyte-stimulating hormone alpha Melanocyte-stimulating hormone alpha 1 Melanotropin alpha Pro-opiomelanocortin Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Neuropeptide Toxicity standard

13 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB03917

Peptide_Name

Alpha-melanocyte-stimulating hormone d-Alpha-MSH Melanocyte-stimulating hormone alpha Melanocyte-stimulating hormone alpha 1 Melanotropin alpha Pro-opiomelanocortin

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Neuropeptide Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb i2APP AI4AVP dbAMP 3.0 B3Pred BBPpredict ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SYSMEHFRWGKPV

FASTA

>TPDB03917|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Blood-Brain Barrier;Neuropeptide;Toxicity|length=13
SYSMEHFRWGKPV

Formula C75H106N20O19S1

Absent Amino Acids ANDCQILT

Common Amino Acids S

Mass 1623.85

PI 9.74

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 5

Net Charge +1

Boman Index 1.42

Hydrophobicity -0.923

Aliphatic Index 22.31

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 430.46

Polar Residues 3

number

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 1 M: 1 F: 1 P: 1 S: 2 T: 0 W: 1 Y: 1 V: 1

Length

Formula

C75H106N20O19S1

Mass

1623.85

9.74

Net Charge

Boman Index

1.42

Hydrophobicity

-0.923

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oryzias latipes

Family POMC

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sparus aurata

Family POMC

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocyte-stimulating hormone receptor

Receptor Organisms Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family POMC

Receptor Lengths 317

Receptor Ligands NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Acipenser transmontanus

Family POMC

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Balaenoptera borealis

Family POMC

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Balaenoptera physalus

Family POMC

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Bos taurus Bos taurus Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family POMC

Receptor Lengths 332 325 317

Receptor Ligands NP08979 NP09082 NP09107 NP09134 NP08979 NP09082 NP09107 NP09134 NP08979 NP09082 NP09107 NP09134

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family POMC

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family POMC

Receptor Lengths 323 332 325 317

Receptor Ligands NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Lepisosteus osseus

Family POMC

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Lithobates catesbeianus

Family POMC

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Loxodonta africana

Family POMC

Evidence 13 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocyte-stimulating hormone receptor

Receptor Organisms Macaca nemestrina

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca nemestrina

Family POMC

Receptor Lengths 317

Receptor Ligands NP09138 NP08985 NP09088 NP09113

Evidence 14 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Mus musculus Mus musculus Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family POMC

Receptor Lengths 323 332 325 315

Receptor Ligands NP08974 NP08986 NP09089 NP09114 NP09139 NP08974 NP08986 NP09089 NP09114 NP09139 NP08974 NP08986 NP09089 NP09114 NP09139 NP08974 NP08986 NP09089 NP09114 NP09139

Evidence 15 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Neovison vison

Family POMC

Evidence 16 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pelophylax ridibundus

Family POMC

Evidence 17 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 4 Melanocyte-stimulating hormone receptor Melanocortin receptor 5

Receptor Organisms Sus scrofa Sus scrofa Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family POMC

Receptor Lengths 332 320 294

Receptor Ligands NP09141 NP08990 NP09093 NP09118 NP09141 NP08990 NP09093 NP09118 NP09141 NP08990 NP09093 NP09118

Evidence 18 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oryctolagus cuniculus

Family POMC

Evidence 19 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family POMC

Receptor Lengths 323 332 325

Receptor Ligands NP08992 NP09095 NP09119 NP09142 NP08102 NP08992 NP09095 NP09119 NP09142 NP08102 NP08992 NP09095 NP09119 NP09142 NP08102

Evidence 20 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Ovis aries Ovis aries

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family POMC

Receptor Lengths 325 317

Receptor Ligands NP09143 NP08993 NP09096 NP09120 NP09143 NP08993 NP09096 NP09120

Evidence 21 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Struthio camelus

Family POMC

Evidence 22 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oncorhynchus mykiss

Family POMC

Evidence 23 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Camelus dromedarius

Family POMC

Evidence 24 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocyte-stimulating hormone receptor

Receptor Organisms Equus caballus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Equus caballus

Family POMC

Receptor Lengths 317

Receptor Ligands NP09131 NP09130

Evidence 25 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family POMC

Evidence 26 Activity

Activity

Activity Endpoint 1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis. | Int J Antimicrob Agents | 2010

Family

POMC

Receptor_Lengths

317 332 325 323 315 320 294

Receptor_Ligands

NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035 NP08979 NP09082 NP09107 NP09134 NP09138 NP08985 NP09088 NP09113 NP08974 NP08986 NP09089 NP09114 NP09139 NP09141 NP08990 NP09093 NP09118 NP08992 NP09095 NP09119 NP09142 NP08102 NP09143 NP08993 NP09096 NP09120 NP09131 NP09130