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Peptide record

TPDB03914

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB03914
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 i2APP ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLWSTIKQKGKEAAIAAAKAAGQAALGAL
Physicochemical Analysis
C125H212N36O36
RNDCHMFPYV
A
2795.28
10.55
4
1
16
+3
1.60
0.286
101.72
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
196.76
4
Residue Composition
number
10
A
0
R
0
N
0
D
0
C
1
E
2
Q
4
G
0
H
2
I
3
L
4
K
0
M
0
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 10 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 2 G: 4 H: 0 I: 2 L: 3 K: 4 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
29
C125H212N36O36
2795.28
10.55
+3
1.60
0.286
Evidence Records 6 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
2 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 2 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. | J Biol Chem | 2002
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human leukocytes

Target

Human leukocytes

Source & Reference

NA
DBAASP
Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. | J Biol Chem | 2002
Evidence 3 Activity

Activity

1% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. | J Biol Chem | 2002
Evidence 4 Activity

Activity

2% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. | J Biol Chem | 2002
Evidence 5 Activity

Activity

14.61±1.20% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
14.61±1.20% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 6 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:8306981]Non-hemolytic activity against rabbit red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2002 Dec 20 277(51):49332-49340. ##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov 151(3):336-343.