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Peptide record

TPDB03903

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB03903
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WLNALLHHGLNCAKGVLA
Physicochemical Analysis
C88H140N26O21S1
RDEQIMFPSTY
L
1930.30
8.97
3
0
10
+1
-1.56
0.672
141.11
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
284.93
3
Residue Composition
number
3
A
0
R
2
N
0
D
1
C
0
E
0
Q
2
G
2
H
0
I
5
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 5 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
18
C88H140N26O21S1
1930.30
8.97
+1
-1.56
0.672
Evidence Records 8 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus MRSA and P. aeruginosa.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against S. aureus MRSA and P. aeruginosa.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

active against S. aureus MRSA and P. aeruginosa.
Evidence 4 Activity

Activity

20% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological activities of synthetic analogs of halocidin, an antimicrobial peptide from the tunicate Halocynthia aurantium | Antimicrob Agents Chemother | 2003
Evidence 5 Activity

Activity

50% Cell death
Toxicity
72.385 µg/mL
Cytotoxic
50% Cell death | 72.385 | µg/mL | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Antifungal Activity and Action Mechanism of Histatin 5-Halocidin Hybrid Peptides against Candida ssp. | PLoS One | 2016
Evidence 6 Activity

Activity

75% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
75% Hemolysis | 128 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antifungal Activity and Action Mechanism of Histatin 5-Halocidin Hybrid Peptides against Candida ssp. | PLoS One | 2016
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. | FEBS Lett | 2002
Evidence 8 Activity

Activity

8% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. | FEBS Lett | 2002