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Peptide record

TPDB03897

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB03897
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept i2APP AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLADFLNKAVGKVVDFVKS
Physicochemical Analysis
C93H151N23O26
RCEQHIMPTWY
V
2007.36
9.76
3
2
10
+1
2.56
0.516
112.63
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
1
N
2
D
0
C
0
E
0
Q
2
G
0
H
0
I
2
L
3
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 2 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 3 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
19
C93H151N23O26
2007.36
9.76
+1
2.56
0.516
Evidence Records 33 records
Evidence 1 Activity

Activity

IC50
Antibacterial
>100 µM

Target

B.cereus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M
Evidence 2 Activity

Activity

IC50
Antibacterial
>100 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP

Other

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au
Evidence 3 Activity

Activity

IC50
Antibacterial
25 µM

Target

L. lactis

Source & Reference

dbAMP DRAMP

Other

ically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >10
Evidence 4 Activity

Activity

IC50
Antibacterial
>100 µM

Target

L.innocua

Source & Reference

dbAMP DRAMP

Other

am+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC1
Evidence 5 Activity

Activity

IC50
Antibacterial
>100 µM

Target

M.luteus ATCC9341

Source & Reference

dbAMP DRAMP

Other

), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC
Evidence 6 Activity

Activity

IC50
Antibacterial
>100 µM

Target

S.aureus ATCC29213

Source & Reference

dbAMP DRAMP

Other

uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC1304
Evidence 7 Activity

Activity

IC50
Antibacterial
>100 µM

Target

S.epidermidis ATCC14990

Source & Reference

dbAMP DRAMP

Other

ocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218
Evidence 8 Activity

Activity

IC50
Antibacterial
50 µM

Target

S. uberis

Source & Reference

dbAMP DRAMP

Other

IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218 (IC50 > 100 uM). Updated
Evidence 9 Activity

Activity

IC50
Antifungal
>100 µM

Target

B.cereus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M
Evidence 10 Activity

Activity

IC50
Antifungal
>100 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP Antifungipept

Other

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au
Evidence 11 Activity

Activity

IC50
Antifungal
25 µM

Target

L. lactis

Source & Reference

dbAMP DRAMP Antifungipept

Other

ically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >10
Evidence 12 Activity

Activity

IC50
Antifungal
>100 µM

Target

L.innocua

Source & Reference

dbAMP DRAMP Antifungipept

Other

am+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC1
Evidence 13 Activity

Activity

IC50
Antifungal
>100 µM

Target

M.luteus ATCC9341

Source & Reference

dbAMP DRAMP Antifungipept

Other

), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC
Evidence 14 Activity

Activity

IC50
Antifungal
>100 µM

Target

S.aureus ATCC29213

Source & Reference

dbAMP DRAMP Antifungipept

Other

uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC1304
Evidence 15 Activity

Activity

IC50
Antifungal
>100 µM

Target

S.epidermidis ATCC14990

Source & Reference

dbAMP DRAMP Antifungipept

Other

ocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218
Evidence 16 Activity

Activity

IC50
Antifungal
50 µM

Target

S. uberis

Source & Reference

dbAMP DRAMP Antifungipept

Other

IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218 (IC50 > 100 uM). Updated
Evidence 17 Activity

Activity

IC50
Antiparasitic
>100 µM

Target

B.cereus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M
Evidence 18 Activity

Activity

IC50
Antiparasitic
>100 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP 3.0 DRAMP

Other

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au
Evidence 19 Activity

Activity

IC50
Antiparasitic
25 µM

Target

L. lactis

Source & Reference

dbAMP 3.0 DRAMP

Other

ically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >10
Evidence 20 Activity

Activity

IC50
Antiparasitic
>100 µM

Target

L.innocua

Source & Reference

dbAMP 3.0 DRAMP

Other

am+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC1
Evidence 21 Activity

Activity

IC50
Antiparasitic
>100 µM

Target

M.luteus ATCC9341

Source & Reference

dbAMP 3.0 DRAMP

Other

), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC
Evidence 22 Activity

Activity

IC50
Antiparasitic
>100 µM

Target

S.aureus ATCC29213

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC1304
Evidence 23 Activity

Activity

IC50
Antiparasitic
>100 µM

Target

S.epidermidis ATCC14990

Source & Reference

dbAMP 3.0 DRAMP

Other

ocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218
Evidence 24 Activity

Activity

IC50
Antiparasitic
50 µM

Target

S. uberis

Source & Reference

dbAMP 3.0 DRAMP

Other

IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218 (IC50 > 100 uM). Updated
Evidence 25 Activity

Activity

IC50
Antiviral
>100 µM

Target

B.cereus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M
Evidence 26 Activity

Activity

IC50
Antiviral
>100 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au
Evidence 27 Activity

Activity

IC50
Antiviral
25 µM

Target

L. lactis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >10
Evidence 28 Activity

Activity

IC50
Antiviral
>100 µM

Target

L.innocua

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

am+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC1
Evidence 29 Activity

Activity

IC50
Antiviral
>100 µM

Target

M.luteus ATCC9341

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC
Evidence 30 Activity

Activity

IC50
Antiviral
>100 µM

Target

S.aureus ATCC29213

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC1304
Evidence 31 Activity

Activity

IC50
Antiviral
>100 µM

Target

S.epidermidis ATCC14990

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218
Evidence 32 Activity

Activity

IC50
Antiviral
50 µM

Target

S. uberis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S. uberis (IC50 50 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218 (IC50 > 100 uM). Updated
Evidence 33 Activity

Activity

50% Cell death
Toxicity
>49.9 µM
Cytotoxic
50% Cell death | >49.9 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010