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Peptide record

TPDB03893

Anti-inflammatory Antibacterial Antifungal Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB03893
Anti-inflammatory Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 dbAMP DRAMP AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
INWLKLGKMVIDAL
Physicochemical Analysis
C76H128N18O18S1
RCEQHFPSTY
L
1614.02
9.88
2
1
9
+1
-0.84
0.871
167.14
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
340.76
1
Residue Composition
number
1
A
0
R
1
N
1
D
0
C
0
E
0
Q
1
G
0
H
2
I
3
L
2
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 2 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C76H128N18O18S1
1614.02
9.88
+1
-0.84
0.871
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against G+ and G- bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref)
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Activity against G+ and G- bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

Activity against G+ and G- bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. a
Evidence 4 Activity

Activity

MIC
Antibacterial
38 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. n
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

, and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. neoformans (EC50 11.0 uM) ( Silva JC et al., 2017 ). P
Evidence 6 Activity

Activity

EC50
Antibacterial
12.9 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. neoformans (EC50 11.0 uM) ( Silva JC et al., 2017 ). Polybia-MPII peptides were ab
Evidence 7 Activity

Activity

EC50
Antibacterial
11.0 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. neoformans (EC50 11.0 uM) ( Silva JC et al., 2017 ). Polybia-MPII peptides were able to inhibit cells that were dis
Evidence 8 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against G+ and G- bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref)
Evidence 9 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Activity against G+ and G- bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against
Evidence 10 Activity

Activity

MIC
Antifungal
5 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Activity against G+ and G- bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. a
Evidence 11 Activity

Activity

MIC
Antifungal
38 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

bacteria such as E. coli (MIC 5 uM), S. aureus (MIC 2 uM), and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. n
Evidence 12 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, and B. cereus (MIC 5 uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. neoformans (EC50 11.0 uM) ( Silva JC et al., 2017 ). P
Evidence 13 Activity

Activity

EC50
Antifungal
12.9 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), and P. aeruginosa (MIC 38 uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. neoformans (EC50 11.0 uM) ( Silva JC et al., 2017 ). Polybia-MPII peptides were ab
Evidence 14 Activity

Activity

EC50
Antifungal
11.0 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM) (this ref). Also active against S. aureus (MIC 2 uM), C. albicans (EC50 12.9 uM) and C. neoformans (EC50 11.0 uM) ( Silva JC et al., 2017 ). Polybia-MPII peptides were able to inhibit cells that were dis
Evidence 15 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Rat polymorphonucleated leukocytes

Target

Rat polymorphonucleated leukocytes

Source & Reference

NA
DBAASP
Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista. | Peptides | 2009
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
24.18 µM
Hemolytic Cytotoxic
50% Hemolysis | 24.18 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera). | Int J Antimicrob Agents | 2017
Evidence 17 Activity

Activity

90% Hemolysis
Toxicity
58.12 µM
Hemolytic Cytotoxic
90% Hemolysis | 58.12 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera). | Int J Antimicrob Agents | 2017
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
48.47 µM
Hemolytic Cytotoxic
50% Hemolysis | 48.47 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera). | Int J Antimicrob Agents | 2017
Evidence 19 Activity

Activity

100% Cytotoxicity
Toxicity
32 µM
Cytotoxic
100% Cytotoxicity | 32 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
The effects of incorporation of the counterparts and mimics of l-lysine on the antimicrobial activity, hemolytic activity, cytotoxicity and tryptic stability of antimicrobial peptide polybia-MPII. | Amino Acids | 2022
Evidence 20 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.