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Peptide record

TPDB03891

Antibacterial Anticancer Antifungal Antiparasitic standard

17 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB03891

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLFDIVKKIAGHIVSSI

FASTA

>TPDB03891|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=17
GLFDIVKKIAGHIVSSI

Formula C84H141N21O22

Absent Amino Acids RNCEQMPTWY

Common Amino Acids I

Mass 1797.17

PI 9.88

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +1

Boman Index 1.49

Hydrophobicity 1.053

Aliphatic Index 154.71

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 4 L: 1 K: 2 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 2

Length

Formula

C84H141N21O22

Mass

1797.17

9.88

Net Charge

Boman Index

1.49

Hydrophobicity

1.053

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. mult

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µg/mL

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ive against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. e

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

00 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml),

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism P. multocida

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (provided by Chunfeng Wang).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (provided by Chunfeng Wang).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (provided by Chunfeng Wang).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. mult

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µg/mL

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S.

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism P. multocida

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (provided by Chunfeng Wang).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (provided by Chunfeng Wang).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. mult

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µg/mL

Target

Target Organism L. lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B.cereus (MIC >100 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 12 ug/ml), L.innocua (MIC >100 ug/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S.

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism P. multocida

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

/ml), M. luteus (MIC 100 ug/ml), P. multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (provided by Chunfeng Wang).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

multocida (MIC 100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), and S. uberis (MIC 25 ug/ml) (provided by Chunfeng Wang).