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Peptide record

TPDB03890

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB03890
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GFFLNALKNFAKTAGKRLKSLLNHASCKLSGQC
Physicochemical Analysis
C159H261N47O42S2
DEIMPWYV
L
3567.23
10.70
7
0
13
+6
1.21
-0.064
83.03
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.50
10
Residue Composition
number
4
A
1
R
3
N
0
D
2
C
0
E
1
Q
3
G
1
H
0
I
6
L
5
K
0
M
3
F
0
P
3
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 3 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 1 I: 0 L: 6 K: 5 M: 0 F: 3 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
33
C159H261N47O42S2
3567.23
10.70
+6
1.21
-0.064
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

Active against Gram- E. coli (MIC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus P
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Klebsiella pneumoniae PTCC1388

Source & Reference

NA

Other

Active against Gram- E. coli (MIC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus PTCC1431 (MIC 12 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
7 µg/mL

Target

B. cereus PTCC1247

Source & Reference

NA

Other

Active against Gram- E. coli (MIC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus PTCC1431 (MIC 12 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

Staphylococcus aureus PTCC1431

Source & Reference

NA

Other

IC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus PTCC1431 (MIC 12 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

Escherichia coli

Source & Reference

Antifungipept

Other

Active against Gram- E. coli (MIC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus P
Evidence 6 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

Klebsiella pneumoniae PTCC1388

Source & Reference

Antifungipept

Other

Active against Gram- E. coli (MIC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus PTCC1431 (MIC 12 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
7 µg/mL

Target

B. cereus PTCC1247

Source & Reference

Antifungipept

Other

Active against Gram- E. coli (MIC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus PTCC1431 (MIC 12 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

Staphylococcus aureus PTCC1431

Source & Reference

Antifungipept

Other

IC 5 ug/ml), K. pneumoniae PTCC1388 (MIC 10 ug/ml), B. cereus PTCC1247 (MIC 7 ug/ml), and S. aureus PTCC1431 (MIC 12 ug/ml).
Evidence 9 Activity

Activity

1% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and modeling amphipathic alpha helical antimicrobial peptides from skin secretions of Euphlyctis cyanophlyctis. | Chem Biol Drug Des | 2014