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Peptide record

TPDB03853

Antibacterial Antifungal Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB03853
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse CAFPdb dbAMP PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GLKDWWNKHKDKIVKVVKEMGKAGINAA
Physicochemical Analysis
C144H235N41O37S1
RCQFPSTY
K
3164.76
10.41
8
3
12
+4
7.83
-0.654
83.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
347.58
2
Residue Composition
number
3
A
0
R
2
N
2
D
0
C
1
E
0
Q
3
G
1
H
2
I
1
L
7
K
1
M
0
F
0
P
0
S
0
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 2 C: 0 E: 1 Q: 0 G: 3 H: 1 I: 2 L: 1 K: 7 M: 1 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 3
Chemical Descriptors
28
C144H235N41O37S1
3164.76
10.41
+4
7.83
-0.654
Evidence Records 4 records
Evidence 1 Activity

Activity

18.7% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
18.7% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 2 Activity

Activity

83.7% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
83.7% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
11.53 µM
Hemolytic Cytotoxic
50% Hemolysis | 11.53 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of synthetic Dq-3162, a 28-residue ponericin G-like dinoponeratoxin from the giant ant Dinoponera quadriceps venom, against carbapenem-resistant bacteria. | Toxicon | 2020
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis