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Peptide record

TPDB03848

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB03848
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GIGASILSAGKSALKGLAKGLAEHFAN
Physicochemical Analysis
C115H193N33O34
RDCQMPTWYV
A
2582.00
10.32
4
1
13
+2
1.80
0.426
108.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
6
A
0
R
1
N
0
D
0
C
1
E
0
Q
5
G
1
H
2
I
4
L
3
K
0
M
1
F
0
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 1 I: 2 L: 4 K: 3 M: 0 F: 1 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
27
C115H193N33O34
2582.00
10.32
+2
1.80
0.426
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica, and N. cinerea (82-100% killing at 20 ug/ml), but did not kill E-coli, K-acyloca, P-aeruginosa, K-pmeumoniae, E-cloacae under the same conditions. Also active against B. megaterium BmII, S. aureus Cowan1, E. coli D21, E. coli D22, Y. pseudotubercolosis, P. aeruginosa ATCC 15692, and C. albicans ( Simmaco et al. 1998 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica, and N. cinerea (82-100% killing at 20 ug/ml), but did not kill E-coli, K-acyloca, P-aeruginosa, K-pmeumoniae, E-cloacae under the same conditions. Also active against B. megaterium BmII, S. aureus Cowan1, E. coli D21, E. coli D22, Y. pseudotubercolosis, P. aeruginosa ATCC 15692, and C. albicans ( Simmaco et al. 1998 ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

NA

Other

active against N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica, and N. cinerea (82-100% killing at 20 ug/ml), but did not kill E-coli, K-acyloca, P-aeruginosa, K-pmeumoniae, E-cloacae under the same conditions. Also active against B. megaterium BmII, S. aureus Cowan1, E. coli D21, E. coli D22, Y. pseudotubercolosis, P. aeruginosa ATCC 15692, and C. albicans ( Simmaco et al. 1998 ).
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis. | J Biol Chem | 1991
Evidence 5 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.1744108] No significant hemolytic activity against human red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 1991 Dec 5 266(34):23103-23111.