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Peptide record

TPDB03832

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB03832
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIGAAILSAGKSALKGLAKGLAEHF
Physicochemical Analysis
C108H182N30O30
RNDCQMPTWYV
A
2380.82
10.32
4
1
13
+2
1.25
0.632
117.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
1
E
0
Q
5
G
1
H
2
I
4
L
3
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 1 I: 2 L: 4 K: 3 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C108H182N30O30
2380.82
10.32
+2
1.25
0.632
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica, and N. cinerea (59-100% at 20 ug/ml), but did not kill E.coli, K.acyloca, P.aeruginosa, K.pmeumoniae, E.cloacae under the same conditions. Also active against B. megaterium BmII, S. aureus Cowan1, E. coli D21, E. coli D22, Y. pseudotubercolosis, P. aeruginosa ATCC 15692, and C. albicans ( Simmaco et al. 1998 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica, and N. cinerea (59-100% at 20 ug/ml), but did not kill E.coli, K.acyloca, P.aeruginosa, K.pmeumoniae, E.cloacae under the same conditions. Also active against B. megaterium BmII, S. aureus Cowan1, E. coli D21, E. coli D22, Y. pseudotubercolosis, P. aeruginosa ATCC 15692, and C. albicans ( Simmaco et al. 1998 ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica, and N. cinerea (59-100% at 20 ug/ml), but did not kill E.coli, K.acyloca, P.aeruginosa, K.pmeumoniae, E.cloacae under the same conditions. Also active against B. megaterium BmII, S. aureus Cowan1, E. coli D21, E. coli D22, Y. pseudotubercolosis, P. aeruginosa ATCC 15692, and C. albicans ( Simmaco et al. 1998 ).
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis. | J Biol Chem | 1991
Evidence 5 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 1991 Dec 5 266(34):23103-23111.