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Peptide record

TPDB03717

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB03717
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
ILIACLGLKLLRYRRIY
Physicochemical Analysis
C98H169N27O20S1
NDEQHMFPSTWV
L
2077.65
10.58
4
0
11
+4
-2.59
0.965
189.41
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
2980
143.43
3
Residue Composition
number
1
A
3
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
3
I
5
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 5 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
17
C98H169N27O20S1
2077.65
10.58
+4
-2.59
0.965
Evidence Records 2 records
Evidence 1 Activity

Activity

LD50
Toxicity
23±1 µM
Cytotoxic
LD50 | 23±1 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae. | Proc Natl Acad Sci U S A | 2020
Evidence 2 Activity

Activity

LD90
Toxicity
47±1 µM
Cytotoxic
LD90 | 47±1 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae. | Proc Natl Acad Sci U S A | 2020