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Peptide record

TPDB03703

LL-37(1-4,17-27) Antibacterial Anticancer Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB03703
LL-37(1-4,17-27)
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LLGDFKRIVQRIKDF
Physicochemical Analysis
C86H142N24O21
ANCEHMPSTWY
RDILKF
1848.22
10.57
4
2
7
+2
2.72
-0.087
123.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
2
D
0
C
0
E
1
Q
1
G
0
H
2
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C86H142N24O21
1848.22
10.57
+2
2.72
-0.087
Free
L
Linear
Free
Antibacterial
LL-37,a series of peptide fragments
Evidence Records 4 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Tumor
KBv
Not Available

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Oral Cancer
KB
Not Available

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006
Evidence 3 Activity

Activity

Not Available
Anticancer

Target

Prostate Cancer
HBMEC
Not Available

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human brain microvascular endothelial cells HBMEC

Target

Human brain microvascular endothelial cells HBMEC

Source & Reference

NA
DBAASP
Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. | J Am Chem Soc | 2006