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Peptide record

TPDB03683

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB03683
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
KKKFPWWWPFKKK
Physicochemical Analysis
C97H136N22O14
ARNDCEQGHILMSTYV
K
1834.29
11.21
6
0
5
+6
-0.97
-1.823
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
899.53
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
2
F
2
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 2 P: 2 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
13
C97H136N22O14
1834.29
11.21
+6
-0.97
-1.823
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Escherichia coli KCTC 1682

Source & Reference

NA

Other

Active against E. coli KCTC 1682 (MIC 2 ug/ml), S. typhimurium KCTC 1926 (MIC 4 ug/ml), B. subtilis KCTC 3068 (MIC 2 ug/ml), and S. aure
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

S. typhimurium KCTC 1926

Source & Reference

NA

Other

Active against E. coli KCTC 1682 (MIC 2 ug/ml), S. typhimurium KCTC 1926 (MIC 4 ug/ml), B. subtilis KCTC 3068 (MIC 2 ug/ml), and S. aureus KCTC 1621 (MIC 2 ug/ml). Nonstandard
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

B. subtilis KCTC 3068

Source & Reference

NA

Other

Active against E. coli KCTC 1682 (MIC 2 ug/ml), S. typhimurium KCTC 1926 (MIC 4 ug/ml), B. subtilis KCTC 3068 (MIC 2 ug/ml), and S. aureus KCTC 1621 (MIC 2 ug/ml). Nonstandard assays in 50% LB.
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Staphylococcus aureus KCTC 1621

Source & Reference

NA

Other

ug/ml), S. typhimurium KCTC 1926 (MIC 4 ug/ml), B. subtilis KCTC 3068 (MIC 2 ug/ml), and S. aureus KCTC 1621 (MIC 2 ug/ml). Nonstandard assays in 50% LB.
Evidence 5 Activity

Activity

IC50
Toxicity
83 µg/mL
Cytotoxic
IC50 | 83 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity. | Biotechnol Lett | 2009
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of perfectly symmetric Trp-rich peptides with potent and broad-spectrum antimicrobial activities. | Int J Antimicrob Agents | 2006
Evidence 7 Activity

Activity

IC50
Toxicity
10 µg/mL
Cytotoxic
IC50 | 10 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity. | Biotechnol Lett | 2009
Evidence 8 Activity

Activity

IC50
Toxicity
83 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: NIH-3T3 (mouse): IC50=83 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Biotechnol Lett. 2009 Feb 31(2):233-7.