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Peptide record

TPDB03676

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB03676
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRIVQRIRDFLR
Physicochemical Analysis
C71H126N28O16
ANCEGHKMPSTWY
R
1627.96
12.58
5
1
5
+4
3.62
-0.808
121.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
5
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C71H126N28O16
1627.96
12.58
+4
3.62
-0.808
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
30 µM

Target

Escherichia coli K12

Source & Reference

NA

Other

active against E. coli K12 (MIC 30 uM).
Evidence 2 Activity

Activity

58% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
58% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural location determines functional roles of the basic amino acids of KR-12, the smallest antimicrobial peptide from human cathelicidin LL-37. | RSC Adv | 2013