TPDB

3D PDB MODEL

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TPDB ID TPDB03662

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.

Sequence

FKLFKKILKFL

FASTA

>TPDB03662|Antibacterial;Hemolysis;Toxicity|length=11
FKLFKKILKFL

Formula C75H121N15O12

Absent Amino Acids ARNDCEQGHMPSTWYV

Common Amino Acids K

Mass 1424.88

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +4

Boman Index -1.42

Hydrophobicity 0.791

Aliphatic Index 141.82

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

3

L

4

K

0

M

3

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 4 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

11

Formula

C75H121N15O12

Mass

1424.88

PI

11.00

Net Charge

+4

Boman Index

-1.42

Hydrophobicity

0.791

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.0-7.5 µM

Target

Target Organism v. syringae

Source & Reference

Database Source NA

Other

Evidence Text

active against plant pathogenic bacterial strains P. syringae pv. syringae (MIC 5.0-7.5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5-5.0 µM

Target

Target Organism v. vesicatoria

Source & Reference

Database Source NA

Other

Evidence Text

nt pathogenic bacterial strains P. syringae pv. syringae (MIC 5.0-7.5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5-5.0 µM

Target

Target Organism E. amylovora

Source & Reference

Database Source NA

Other

Evidence Text

ringae pv. syringae (MIC 5.0-7.5 uM), X. axonopodis pv. vesicatoria (MIC 2.5-5.0 uM), and E. amylovora (MIC 2.5-5.0 uM).

Evidence 4 Activity

Activity

Activity Endpoint 63% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

63% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A library of linear undecapeptides with bactericidal activity against phytopathogenic bacteria. | Peptides | 2007

Evidence 5 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis