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Peptide record

TPDB03661

Antibacterial Anticancer Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB03661
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
LKLFKKILKFL
Physicochemical Analysis
C72H123N15O12
ARNDCEQGHMPSTWYV
LK
1390.86
11.00
4
0
7
+4
-0.85
0.882
177.27
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
4
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C72H123N15O12
1390.86
11.00
+4
-0.85
0.882
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5-5.0 µM

Target

v. syringae

Source & Reference

NA

Other

active against plant pathogenic bacterial strains P. syringae pv. syringae (MIC 2.5-5.0 uM), X. axonopodis pv. vesicatoria (MIC 2.5 uM or less), and E. amylovora (MIC 2.5-5.0 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5-5.0 µM

Target

E. amylovora

Source & Reference

NA

Other

ae pv. syringae (MIC 2.5-5.0 uM), X. axonopodis pv. vesicatoria (MIC 2.5 uM or less), and E. amylovora (MIC 2.5-5.0 uM).
Evidence 3 Activity

Activity

(65±1.5)% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
(65±1.5)% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 4 Activity

Activity

IC50
Toxicity
15.5±0.7 µM
Cytotoxic
IC50 | 15.5±0.7 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties. | Org Biomol Chem | 2014
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis