TPDB

3D PDB MODEL

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TPDB ID TPDB03643

Activity

Antibacterial Anticancer Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.

Sequence

KLLKKFKKLQ

FASTA

>TPDB03643|Antibacterial;Anticancer;Hemolysis;Toxicity|length=10
KLLKKFKKLQ

Formula C62H112N16O12

Absent Amino Acids ARNDCEGHIMPSTWYV

Common Amino Acids K

Mass 1273.67

PI 11.12

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +5

Boman Index 2.72

Hydrophobicity -0.880

Aliphatic Index 117.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

3

L

5

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C62H112N16O12

Mass

1273.67

PI

11.12

Net Charge

+5

Boman Index

2.72

Hydrophobicity

-0.880

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Hemolysis

Activity Measurement 73

Hemolysis Raw

Human erythrocytes: 73 ± 1.6% Hemolysis=375 µM IC50=73 ± 1.6 µM

Target

RBC Target Human erythrocytes

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Peptides. 2010 Nov 31(11):2017-26

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 73% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 375 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

73% Hemolysis | 375 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 73

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: 73 ± 1.6% Hemolysis=375 µM IC50=73 ± 1.6 µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2010 Nov 31(11):2017-26

Evidence 4 Hemolysis

Activity

Activity Measurement 73

Activity Endpoint IC50

Hemolysis Raw

Human erythrocytes: 73 ± 1.6% Hemolysis=375 µM IC50=73 ± 1.6 µM

Detail Source Activity Hemolysis

Target

RBC Target Human erythrocytes

Source & Reference

source HemoPI PD_Hemolysis

Reference

Peptides. 2010 Nov 31(11):2017-26

Source DRAMP4

Database Source PD_Hemolysis