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Peptide record

TPDB03641

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB03641
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
CLRPSIISRA
Physicochemical Analysis
C47H86N16O13S1
NDEQGHKMFTWYV
RIS
1115.36
10.90
2
0
4
+2
0.74
0.490
127.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
2
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
2
I
1
L
0
K
0
M
0
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C47H86N16O13S1
1115.36
10.90
+2
0.74
0.490
Evidence Records 2 records
Evidence 1 Activity

Activity

7% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
7% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and characterization of New Delhi metallo-beta-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae. | J Antimicrob Chemother | 2020
Evidence 2 Activity

Activity

0% Killing
Toxicity
256 µM
Cytotoxic
0% Killing | 256 | µM | target cell: Murine intestinal epithelial cells MODE-K

Target

Murine intestinal epithelial cells MODE-K

Source & Reference

NA
DBAASP
Discovery and characterization of New Delhi metallo-beta-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae. | J Antimicrob Chemother | 2020