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Peptide record

TPDB03579

Antibacterial Antifungal Hemolysis Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB03579
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GIWSSIKNLASKAWNSDIGQSLRNKAAGAINKFVADKIGVTPSQAAS
Physicochemical Analysis
C215H349N63O66
CEHMY
A
4872.52
10.70
6
2
20
+4
3.88
-0.162
87.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
225.76
14
Residue Composition
number
8
A
1
R
4
N
2
D
0
C
0
E
2
Q
4
G
0
H
5
I
2
L
5
K
0
M
1
F
1
P
7
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 8 R: 1 N: 4 D: 2 C: 0 E: 0 Q: 2 G: 4 H: 0 I: 5 L: 2 K: 5 M: 0 F: 1 P: 1 S: 7 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
47
C215H349N63O66
4872.52
10.70
+4
3.88
-0.162
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
17.7-100 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
terial activity against clinical isolates of Gram-negative multidrug resistant pathogens: P. aeruginosa 5 strains (MIC 17.7-100 uM), K. pneumoniae 5 strains (MIC 17.7-50 uM), E. coli IC (4.4-20 uM), E. cloacae strains (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
17.7-50 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

f Gram-negative multidrug resistant pathogens: P. aeruginosa 5 strains (MIC 17.7-100 uM), K. pneumoniae 5 strains (MIC 17.7-50 uM), E. coli IC (4.4-20 uM), E. cloacae strains (MIC 4.4 uM and >20 uM) and A. baumanii 3 str
Evidence 3 Activity

Activity

MIC
Antibacterial
5-20 µM

Target

A. baumanii

Source & Reference

dbAMP

Other

(MIC 17.7-50 uM), E. coli IC (4.4-20 uM), E. cloacae strains (MIC 4.4 uM and >20 uM) and A. baumanii 3 strains (MIC 5-20 uM) causing nosocomial infections.
Evidence 4 Activity

Activity

MIC
Antifungal
17.7-100 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
terial activity against clinical isolates of Gram-negative multidrug resistant pathogens: P. aeruginosa 5 strains (MIC 17.7-100 uM), K. pneumoniae 5 strains (MIC 17.7-50 uM), E. coli IC (4.4-20 uM), E. cloacae strains (MI
Evidence 5 Activity

Activity

MIC
Antifungal
17.7-50 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP Antifungipept

Other

f Gram-negative multidrug resistant pathogens: P. aeruginosa 5 strains (MIC 17.7-100 uM), K. pneumoniae 5 strains (MIC 17.7-50 uM), E. coli IC (4.4-20 uM), E. cloacae strains (MIC 4.4 uM and >20 uM) and A. baumanii 3 str
Evidence 6 Activity

Activity

MIC
Antifungal
5-20 µM

Target

A. baumanii

Source & Reference

dbAMP Antifungipept

Other

(MIC 17.7-50 uM), E. coli IC (4.4-20 uM), E. cloacae strains (MIC 4.4 uM and >20 uM) and A. baumanii 3 strains (MIC 5-20 uM) causing nosocomial infections.
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus. | Toxicon | 2011
Evidence 8 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.