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Peptide record

TPDB03566

Antibacterial Anticancer Antifungal Antiparasitic standard

43 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB03566

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 43-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GKIPVKAIKKGGQIIGKALRGINIASTAHDIISQFKPKKKKNH

FASTA

>TPDB03566|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=43
GKIPVKAIKKGGQIIGKALRGINIASTAHDIISQFKPKKKKNH

Formula C210H364N64O53

Absent Amino Acids CEMWY

Common Amino Acids K

Mass 4633.60

PI 11.42

Basic Residues 13

Acidic Residues 1

Hydrophobic Residues 15

Net Charge +10

Boman Index 12.43

Hydrophobicity -0.486

Aliphatic Index 97.67

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 7

number

Amino Acid Distribution

A: 4 R: 1 N: 2 D: 1 C: 0 E: 0 Q: 2 G: 5 H: 2 I: 8 L: 1 K: 10 M: 0 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C210H364N64O53

Mass

4633.60

11.42

Net Charge

+10

Boman Index

12.43

Hydrophobicity

-0.486

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against bacteria E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against bacteria E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100 uM), L. maculans (MIC 1

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against bacteria E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100 uM), L. maculans (MIC 100 uM). Inactive: fungi (mycelia) F. gramin

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100 uM), L. maculans (MIC 100 uM). Inactive: fungi (mycelia) F. graminearum (MIC 280 uM), and F.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism L. maculans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100 uM), L. maculans (MIC 100 uM). Inactive: fungi (mycelia) F. graminearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fu

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 280 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 10 uM), F. oxysporum (MIC 100 uM), L. maculans (MIC 100 uM). Inactive: fungi (mycelia) F. graminearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (M

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 280 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), L. maculans (MIC 100 uM). Inactive: fungi (mycelia) F. graminearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism A.niger

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ungi (mycelia) F. graminearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism C.gloeosporioides

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

inearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against bacteria E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against bacteria E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100 uM), L. maculans (MIC 1

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism L. maculans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 280 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 280 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism A.niger

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ungi (mycelia) F. graminearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism C.gloeosporioides

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

inearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against bacteria E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against bacteria E. coli (MIC 100 uM), M. luteus (MIC 100 uM), fungi (spore): F. graminearum (MIC 10 uM), F. oxysporum (MIC 100 uM), L. maculans (MIC 1

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism L. maculans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 280 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 280 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >150 µM

Target

Target Organism A.niger

Source & Reference

Database Source DRAMP

Other

Evidence Text

ungi (mycelia) F. graminearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >150 µM

Target

Target Organism C.gloeosporioides

Source & Reference

Database Source DRAMP

Other

Evidence Text

inearum (MIC 280 uM), and F. oxysporum (MIC 280 uM). fungi (spore): A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021