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Peptide record

TPDB03469

Antibacterial Anticancer Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB03469
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWKVFKKIEKKWKVFKKIEKAGPKWKVFKKIEK
Physicochemical Analysis
C208H335N51O40
RNDCQHLMSTY
K
4190.27
10.95
15
3
13
+12
11.54
-1.133
64.85
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
393.77
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
3
E
0
Q
1
G
0
H
3
I
0
L
15
K
0
M
3
F
1
P
0
S
0
T
3
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 3 Q: 0 G: 1 H: 0 I: 3 L: 0 K: 15 M: 0 F: 3 P: 1 S: 0 T: 0 W: 3 Y: 0 V: 3
Chemical Descriptors
33
C208H335N51O40
4190.27
10.95
+12
11.54
-1.133
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human lymphoblast cells RPMI-7666

Target

Human lymphoblast cells RPMI-7666

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>50 µM
Cytotoxic
50% Cell death | >50 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human fibroblasts WI-38

Target

Human fibroblasts WI-38

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 4 Activity

Activity

18% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
18% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and function of a custom anticancer peptide, CB1a. | Peptides | 2009
Evidence 5 Activity

Activity

IC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 18% Hemolysis=200 µM | Cytotoxicity: RPMI-7666: IC50>100 µM NIH 3T3: IC50>50 µM WI-38: IC50>100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2009 May 30(5):839-48.