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Peptide record

TPDB03467

Antibacterial Anticancer Antifungal Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB03467
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RRIPFWPPNWPGPWLPPWSPPDFRIPRILRKR
Physicochemical Analysis
C197H288N56O37
ACEQHMTYV
P
4032.81
12.70
7
1
11
+6
0.43
-1.000
60.94
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
545.53
2
Residue Composition
number
0
A
6
R
1
N
1
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
1
K
0
M
2
F
10
P
1
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 1 M: 0 F: 2 P: 10 S: 1 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
32
C197H288N56O37
4032.81
12.70
+6
0.43
-1.000
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
7 µM

Target

Escherichia coli BW25113

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli BW25113 (MIC 7 uM). The peptide also contains multiple Trp (althought not rich <25%). Its mechanism of actio
Evidence 2 Activity

Activity

MIC
Antifungal
7 µM

Target

Escherichia coli BW25113

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli BW25113 (MIC 7 uM). The peptide also contains multiple Trp (althought not rich <25%). Its mechanism of actio
Evidence 3 Activity

Activity

1% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
1% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 4 Activity

Activity

10% Killing
Toxicity
32 µM
Cytotoxic
10% Killing | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020