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Peptide record

TPDB03458

Antibacterial Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB03458
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
ARARCRRGRAARRRRLRGVCRIRGRLRRLAAR
Physicochemical Analysis
C155H296N80O33S2
NDEQHKMFPSTWY
R
3872.69
13.04
16
0
11
+16
9.57
-1.166
76.56
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
3.23
2
Residue Composition
number
6
A
16
R
0
N
0
D
2
C
0
E
0
Q
3
G
0
H
1
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 6 R: 16 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
32
C155H296N80O33S2
3872.69
13.04
+16
9.57
-1.166
Evidence Records 5 records
Evidence 1 Activity

Activity

30% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
30% Hemolysis | 25 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 2 Activity

Activity

42% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
42% Hemolysis | 50 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 3 Activity

Activity

65% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
65% Hemolysis | 100 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 4 Activity

Activity

5% Killing
Toxicity
150 µg/mL
Cytotoxic
5% Killing | 150 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis