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Peptide record

TPDB03447

Antibacterial Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB03447
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 31-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
LSLIAAAGKETIRQYLKNEIKKKGRKAVIAW
Physicochemical Analysis
C160H274N46O41
DCHMFP
K
3498.22
10.85
8
2
15
+6
6.40
-0.268
113.55
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
6990
199.82
5
Residue Composition
number
5
A
2
R
1
N
0
D
0
C
2
E
1
Q
2
G
0
H
4
I
3
L
6
K
0
M
0
F
0
P
1
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 4 L: 3 K: 6 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
31
C160H274N46O41
3498.22
10.85
+6
6.40
-0.268
Evidence Records 2 records
Evidence 1 Activity

Activity

25% Cytotoxicity
Toxicity
32 µM
Cytotoxic
25% Cytotoxicity | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. | J Antibiot (Tokyo) | 2018
Evidence 2 Activity

Activity

35% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
35% Hemolysis | 32 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. | J Antibiot (Tokyo) | 2018